EBC-1Homo sapiens (Human)Cancer cell line

Also known as: EBC1, EBC-1/original

🤖 AI SummaryBased on 14 publications

Quick Overview

EBC-1 is a human squamous cell carcinoma cell line used in cancer research.

Detailed Summary

EBC-1 is a human squamous cell carcinoma cell line derived from a patient with squamous cell carcinoma. It is widely used in research to study the molecular mechanisms of cancer, particularly in the context of lung and head and neck cancers. This cell line has been utilized in studies involving genetic mutations, such as those in the EGFR and PARD3 genes, and has been part of investigations into the role of tumor suppressor genes like DBC1 and FAT. EBC-1 is also used to evaluate the efficacy of targeted therapies and to understand the genetic and epigenetic changes associated with cancer progression.

Research Applications

Genetic mutation analysisTumor suppressor gene studiesEGFR and PARD3 gene researchDBC1 and FAT gene investigationsTargeted therapy efficacy testing

Key Characteristics

Squamous cell carcinoma originUsed in lung and head and neck cancer researchPart of studies on genetic and epigenetic changes in cancer

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2891
Species	Homo sapiens (Human)
Tissue Source	Skin[UBERON:UBERON_0002097]

Donor Information

Age	69
Age Category	Adult
Sex	Male

Disease Information

Disease	Lung squamous cell carcinoma
Lineage	Lung
Subtype	Lung Squamous Cell Carcinoma
OncoTree Code	LUSC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000563_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu171Ter (c.511G>T)	Unspecified	-	PubMed=9887230, PubMed=7503188
MutationSimple	EGFR	p.Leu858Arg (c.2573T>G)	Unspecified	In 10% of cells	PubMed=31882684
MutationSimple	DDR2	p.Thr681Ile (c.2042C>T)	Heterozygous	-	from parent cell line EBC-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

8,9

D18S51

12,17

D21S11

29,30

D3S1358

D5S818

D7S820

10,11

D8S1179

FGA

Penta D

Penta E

TH01

TPOX

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.

Kasai F., Fukushima M., Miyagi Y., Nakamura Y.

Hum. Cell 37:944-950(2024).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Functional analysis of discoidin domain receptor 2 mutation and expression in squamous cell lung cancer.

Sueoka E., Kimura S., Sueoka-Aragane N.

Lung Cancer 110:35-41(2017).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.

Igishi T., Burioka N., Nanba E., Shimizu E.

Cancer Biol. Ther. 13:369-378(2012).

DOI PubMed

Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.

Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.

Cancer Sci. 101:1891-1896(2010).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

A gene-alteration profile of human lung cancer cell lines.";

Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.

Hum. Mutat. 30:1199-1206(2009).

DOI PubMed PMC

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.

Hamakawa H.

Oncogene 26:5300-5308(2007).

DOI PubMed

Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.

Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.

Cancer Res. 65:7276-7282(2005).

DOI PubMed

Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Hirohashi S., Inazawa J., Imoto I.

Hum. Mol. Genet. 14:997-1007(2005).

DOI PubMed

Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.

Fujisawa T.

Cancer Immunol. Immunother. 53:786-792(2004).

DOI PubMed PMC

TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.

Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.

Clin. Cancer Res. 9:4705-4713(2003).

PubMed

Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.

Hayashi S., Aozasa K., Kawase I.

Oncogene 22:674-687(2003).

DOI PubMed

Mutation and expression of the DCC gene in human lung cancer.";

Yokota J.

Neoplasia 2:300-305(2000).

DOI PubMed PMC

Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.

Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.

Int. J. Oncol. 15:927-934(1999).

DOI PubMed

Establishment of a drug sensitivity panel using human lung cancer cell lines.

Kohara H., Harada M.

Acta Med. Okayama 53:67-75(1999).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.

Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.

Anticancer Drug Des. 8:417-428(1993).

PubMed

Experimental model of human lung cancer, Part II. Heterotransplantation of human continuous cell lines from squamous cell carcinoma and adenocarcinoma of the lung.

Watanabe Y.

Okayama Igakkai Zasshi 97:701-712(1985).

DOI

Experimental model of human lung cancer, Part I. Establishment and characterization of new tissue culture cell lines from human squamous cell carcinoma and adenocarcinoma of the lung.

Watanabe Y.

Okayama Igakkai Zasshi 97:691-700(1985).

DOI

Establishment of human continuous cell lines from squamous cell, adeno- and small cell carcinoma of the lung and the results of heterotransplantation.

Ikeda H., Nakata Y., Ohnoshi T., Kimura I.

Nihon Haigan Gakkai 22:53-58(1982).

DOI

Web Resources

thermofisher.com