Fu97Homo sapiens (Human)Cancer cell line

Also known as: FU-97, FU97

🤖 AI SummaryBased on 8 publications

Quick Overview

Human gastric cancer cell line with AFP production, tumorigenic in nude mice.

Detailed Summary

The Fu97 cell line is a human gastric cancer-derived cell line established from a 66-year-old female patient. It produces alpha-fetoprotein (AFP) and exhibits tumorigenic potential in nude mice. The cells display an epithelial morphology with large nuclei and cytoplasmic granules. AFP production was detected in both the culture medium and cells, with a molecular weight of approximately 80 kDa. The cell line shows slow growth with a doubling time of about 72 hours. It has been used to study the biological activities of AFP and its potential as an immunological target in cancer therapy.

Research Applications

Cancer biologyAFP production studiesTumorigenicity in nude miceImmunological target identification

Key Characteristics

AFP-producingTumorigenic in nude miceEpithelial morphologySlow growth rate
Generated on 6/19/2025

Basic Information

Database IDCVCL_2908
SpeciesHomo sapiens (Human)
Tissue SourceStomach[UBERON:UBERON_0000945]

Donor Information

Age66
Age CategoryAdult
SexFemale
Raceasian

Disease Information

DiseaseGastric adenocarcinoma
LineageEsophagus/Stomach
SubtypeDiffuse Type Stomach Adenocarcinoma
OncoTree CodeDSTAD

DepMap Information

Source TypeHSRRB
Source IDACH-000633_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Tyr220Asp (c.658T>G)Unspecified-PubMed=27693639

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12
D13S317
10,12
D16S539
9,11
D18S51
15
D21S11
30
D3S1358
16,17
D5S818
10,12
D7S820
11
D8S1179
14,15
FGA
19
Penta D
14
Penta E
15
TH01
9
TPOX
12
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Establishment of an alpha-fetoprotein-producing cell line derived from gastric cancer.

Iwai Y.

In Vitro Cell. Dev. Biol. Anim. 35:555-557(1999).

Web Resources