HCC-56Homo sapiens (Human)Cancer cell line

Also known as: HCC56

🤖 AI SummaryBased on 5 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origins, used in cancer research.

Detailed Summary

HCC-56 is a human cancer cell line with unknown tissue and disease origins. It is utilized in cancer research to study various aspects of tumor biology and drug sensitivity. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive genomic and pharmacological data for a wide range of cancer cell lines. Research on HCC-56 focuses on understanding the genetic and molecular mechanisms underlying cancer progression and response to therapeutic agents. The CCLE data includes information on gene expression, chromosomal copy number, and drug sensitivity profiles, which are essential for developing predictive models of anticancer drug efficacy. Despite its inclusion in large-scale studies, specific details about the tissue of origin and disease type remain unspecified in the available data.

Research Applications

Cancer researchDrug sensitivity profilingGenomic and pharmacological data analysis

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used for studying tumor biology and drug responseIncludes genomic and pharmacological data for predictive modeling

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2917
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age Category	Unknown
Sex	Unknown

Disease Information

Disease	Gastric tubular adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000467_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg196Pro (c.587G>C)	Homozygous	-	Unknown, Unknown
MutationSimple	KRAS	p.Gly12Val (c.35G>T)	Heterozygous	Acquired	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

12,13

D13S317

8,9

D16S539

10,12

D5S818

10,14

D7S820

10,12

TH01

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC