HEC-108Homo sapiens (Human)Cancer cell line

Also known as: HEC108

🤖 AI SummaryBased on 7 publications

Quick Overview

Human endometrial cancer cell line for research on tumor biology and drug sensitivity.

Detailed Summary

HEC-108 is a human endometrial cancer cell line established from a primary tumor. It is used in research to study tumor biology, drug sensitivity, and molecular mechanisms of endometrial carcinoma. The cell line has been characterized for its growth patterns, genetic features, and response to hormonal treatments. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in studies related to gene expression, mutation analysis, and therapeutic strategies. HEC-108 exhibits specific cellular and molecular traits that make it a valuable model for investigating endometrial cancer progression and treatment responses.

Research Applications

Tumor biologyDrug sensitivityMolecular mechanismsGene expression analysisMutation analysisTherapeutic strategies

Key Characteristics

Established from primary tumorPart of CCLEUsed in hormone response studiesCharacterized for growth patternsUtilized in drug screening

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2923
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age Category	Unknown
Sex	Female
Race	asian

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000990_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro151His (c.452C>A)	Unspecified	-	PubMed=33802339, PubMed=11799138, PubMed=8782485, PubMed=8725545
MutationSimple	ARID1A	p.Arg1446Ter (c.4336C>T)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

9,10,11,12,13

D16S539

11,12,13

D18S51

11,12,13

D19S433

11.2,12.2,14.2,15.2,16.2

D21S11

29,30,31

D2S1338

16,17,19,20

D3S1358

15,16,17

D5S818

6,12

D7S820

8,9,12

D8S1179

11,13

FGA

22,23

Penta D

8,9,10

Penta E

15,19,20

TH01

8,9

TPOX

vWA

15,16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

PubMed

Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.

Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.

Gynecol. Oncol. 90:297-304(2003).

DOI PubMed

Experimental studies on the cell adhesion molecule E-cadherin and in vitro invasion of endometrial carcinoma cell lines.

Okamura N., Mori Y., Endo T., Ito E., Kudo R.

Nihon Sanka Fujinka Gakkai Zasshi 48:335-342(1996).

PubMed

Establishment and characterization of human endometrial cancer cell lines.

Ohno E., Iida T.

Ann. N. Y. Acad. Sci. 622:402-421(1991).

DOI PubMed

The results of primary culture of endometrial adenocarcinoma and characterization of its established cell line.

Morisawa T.

Nihon Rinsho Saibo Gakkai Zasshi 26:433-442(1987).

DOI

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

DOI

Web Resources

tcpaportal.org