HEC-116Homo sapiens (Human)Cancer cell line
Also known as: HEC116
🤖 AI SummaryBased on 2 publications
Quick Overview
Human endometrial cancer cell line for research
Detailed Summary
HEC-116 is a human endometrial cancer cell line established from endometrial carcinoma tissue. It is used in research to study the characteristics of endometrial cancer cells, including their growth patterns, morphology, and response to hormonal treatments. The cell line has been characterized for its ability to form tumors when transplanted into animals, making it a valuable model for studying cancer progression and therapeutic interventions. HEC-116 cells exhibit specific cellular features such as jigsaw puzzle-like arrangements and glandular formations, which are indicative of their malignant potential. The cell line's responsiveness to estrogen and progesterone receptors has been documented, highlighting its utility in hormone-related cancer research.
Research Applications
Cancer researchHormone receptor studiesTumor transplantation models
Key Characteristics
Endometrial carcinoma cell lineTransplantable to heterologous animalsMalignant cell features (jigsaw puzzle-like arrangement, glandular formations)
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2924 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Endometrium[UBERON:UBERON_0001295] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Endometrial adenocarcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Endometrial Carcinoma |
| OncoTree Code | UCEC |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001518_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| MutationSimple | PTEN | p.Arg173Cys (c.517C>T) | Homozygous | - | from parent cell line Reh |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8,11
D16S539
9
D18S51
17,25
D19S433
14,16.2
D21S11
29
D2S1338
20,21
D3S1358
17
D5S818
11,12
D7S820
10,12
D8S1179
14
FGA
23,25
Penta D
12,13
Penta E
14,18
TH01
6,8
TPOX
11
vWA
20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
Eur. J. Gynaecol. Oncol. 25:55-60(2004).
Establishment and characterization of human endometrial cancer cell lines.
Ohno E., Iida T.
Ann. N. Y. Acad. Sci. 622:402-421(1991).
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
Kawaguchi M.
(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).