HEC-151Homo sapiens (Human)Cancer cell line

Also known as: HEC151

🤖 AI SummaryBased on 4 publications

Quick Overview

Human endometrial cancer cell line for research on hormone responsiveness and tumor biology.

Detailed Summary

HEC-151 is a human endometrial cancer cell line established from primary tumor tissue. It is used in research to study the characteristics of endometrial carcinoma, including hormone responsiveness and tumor growth patterns. The cell line has been characterized for its chromosomal constitution and has shown potential for in vitro studies on endometrial cancer. It is part of a collection of cell lines that have been established through long-term culture trials, with specific applications in understanding the molecular mechanisms of endometrial cancer. The cell line's ability to maintain certain features of the original tumor makes it a valuable tool for in vitro studies.

Research Applications

Hormone responsiveness studiesTumor biology analysisChromosomal constitution analysis

Key Characteristics

Established from primary tumor tissueUsed for in vitro studies on endometrial cancerMaintains features of original tumor

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2925
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age Category	Unknown
Sex	Female
Race	asian

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000972_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val31Ile (c.91G>A)	Unspecified	-	PubMed=19710698, PubMed=19220422
MutationSimple	PIK3CA	p.Cys420Arg (c.1258T>C)	Heterozygous	-	from parent cell line JIMT-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

7,11

D13S317

8,13,14

D16S539

9,11

D18S51

13,23,24

D19S433

13,14

D21S11

D2S1338

19,20,24

D3S1358

14,15

D5S818

10,13,14

D7S820

8,11

D8S1179

12,13

FGA

19.1,22,23,24

Penta D

8.4,9,10

Penta E

13,14,19

TH01

6,9

TPOX

8,11

vWA

14,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

PubMed

Establishment and characterization of human endometrial cancer cell lines.

Ohno E., Iida T.

Ann. N. Y. Acad. Sci. 622:402-421(1991).

DOI PubMed

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

DOI