HEC-251Homo sapiens (Human)Cancer cell line

Also known as: HEC251

🤖 AI SummaryBased on 4 publications

Quick Overview

Human endometrial cancer cell line for research.

Detailed Summary

HEC-251 is a human endometrial cancer cell line derived from a patient with endometrial carcinoma. It is commonly used in cancer research to study tumor biology, drug sensitivity, and genetic mutations. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in studies involving genomic and proteomic profiling. Research on HEC-251 has contributed to understanding the molecular mechanisms of endometrial cancer and has been instrumental in developing targeted therapies. The cell line is also used to evaluate the efficacy of anticancer drugs and to investigate the role of specific genetic alterations in cancer progression.

Research Applications

Cancer researchDrug sensitivity testingGenomic and proteomic profilingTargeted therapy development

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used for studying endometrial cancer biologyUtilized in drug efficacy studies

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2927
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	53
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Endometrial carcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000996_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ser241Tyr (c.722C>A)	Homozygous	-	Unknown, Unknown
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown
MutationSimple	TP53	p.Gly154Asp (c.461G>A)	Unspecified	-	PubMed=15053063
MutationSimple	RB1	p.Arg552Ter (c.1654C>T)	Homozygous	-	Unknown, Unknown
MutationSimple	PTEN	p.Glu299Ter (c.895G>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	FBXW7	p.Arg479Gln (c.1436G>A)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,11

D13S317

D16S539

D18S51

13,20

D19S433

14,15

D21S11

30,31.2

D2S1338

16,19

D3S1358

15,16

D5S818

9,12

D7S820

D8S1179

10,13

FGA

20,21

Penta D

9,10

Penta E

5,15

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment and characterization of two different types of new human endometrial adenocarcinoma cell lines (HEC-251 and HEC-265).

Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:299-304(2004).

PubMed

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

PubMed

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

DOI

Web Resources

tcpaportal.org