HEC-265Homo sapiens (Human)Cancer cell line

Also known as: HEC265

🤖 AI SummaryBased on 4 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origin, used in cancer research.

Detailed Summary

HEC-265 is a human cancer cell line with unknown tissue and disease origins. It is utilized in cancer research to study various aspects of tumor biology and drug sensitivity. While specific details about its tissue of origin and disease characteristics are not available, it is part of broader efforts to characterize cancer cell lines for their genomic and molecular profiles. This cell line contributes to the understanding of cancer mechanisms and potential therapeutic targets, although further research is needed to elucidate its specific properties and applications.

Research Applications

Cancer researchDrug sensitivity studies

Key Characteristics

Human originUsed in preclinical studies

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2928
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	59
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000946_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	CTNNB1	p.Asp32Val (c.95A>T)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

11,12

D16S539

D18S51

15,18

D19S433

14,16.2

D21S11

D2S1338

22,24

D3S1358

14,15

D5S818

10,12

D7S820

10,11

D8S1179

14,15,16

FGA

20,22,23

Penta D

Penta E

14,16

TH01

TPOX

9,11

vWA

19,22

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment and characterization of two different types of new human endometrial adenocarcinoma cell lines (HEC-251 and HEC-265).

Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:299-304(2004).

PubMed

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

PubMed

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

DOI

Web Resources

tcpaportal.org