HEC-50BHomo sapiens (Human)Cancer cell line

Also known as: Hec50, HEC50, HEC-50, HEC-50 clone B, HEC50B

🤖 AI SummaryBased on 8 publications

Quick Overview

Human endometrial cancer cell line for research on tumor biology and drug development.

Detailed Summary

HEC-50B is a human endometrial cancer cell line derived from endometrial carcinoma. It is used in studies focusing on the molecular mechanisms of cancer progression, drug sensitivity, and genetic characteristics. Research has shown that HEC-50B exhibits specific patterns of gene expression and mutations, making it a valuable model for investigating endometrial cancer. The cell line has been characterized for its growth properties, chromosomal abnormalities, and response to various therapeutic agents. It is also utilized in studies related to hormone receptor status and tumor microenvironment interactions.

Research Applications

Molecular mechanisms of cancer progressionDrug sensitivity profilingGenetic and chromosomal analysisHormone receptor studiesTumor microenvironment interactions

Key Characteristics

Expresses specific gene mutations associated with endometrial cancerDemonstrates distinct growth patterns in vitroResponsive to hormonal and therapeutic agentsUsed in studies of tumor biology and drug development

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2929
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age Category	Unknown
Sex	Female
Race	asian

Disease Information

Disease	Type II endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000831_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757
MutationSimple	AKT1	p.Glu40Lys (c.118G>A)	Homozygous	-	from parent cell line HEC-50B

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

D18S51

D19S433

D21S11

30,31

D2S1338

D3S1358

15,16

D5S818

D7S820

D8S1179

10,15

FGA

Penta D

Penta E

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.

Lessey B.A., Jordan V.C., Bradford A.P.

Gynecol. Oncol. 127:241-248(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

PubMed

Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.

Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.

Gynecol. Oncol. 90:297-304(2003).

DOI PubMed

In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum.

Ohta H., Sakamoto H., Satoh K.

Cancer Lett. 134:111-118(1998).

DOI PubMed

Establishment and characterization of human endometrial cancer cell lines.

Ohno E., Iida T.

Ann. N. Y. Acad. Sci. 622:402-421(1991).

DOI PubMed

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

DOI

Web Resources

tcpaportal.org