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HEC-59Homo sapiens (Human)Cancer cell line

Also known as: Hec59, HEC59

🤖 AI SummaryBased on 8 publications

Quick Overview

Human endometrial adenocarcinoma cell line for cancer research.

Detailed Summary

HEC-59 is a human endometrial adenocarcinoma cell line established from a primary tumor. It is used in research for studying endometrial cancer biology, drug sensitivity, and molecular mechanisms. The cell line exhibits characteristics of epithelial cells with a jigsaw puzzle-like arrangement and piling-up tendencies. It has been utilized in studies involving hormone responsiveness, genetic mutations, and therapeutic targeting. HEC-59 is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genomic and proteomic profiles, contributing to understanding cancer progression and treatment responses.

Research Applications

Cancer biology researchDrug sensitivity testingHormone receptor studiesGenomic and proteomic profiling

Key Characteristics

Epithelial cell morphologyJigsaw puzzle-like arrangementPiling-up tendencyHormone responsiveness

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2930
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age Category	Unknown
Sex	Female
Race	asian

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000994_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	TP53	p.Ser95Phe (c.284C>T)	Heterozygous	-	Unknown
MutationSimple	PTEN	p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA)	Heterozygous	-	Unknown, Unknown, PubMed=25230021
MutationSimple	PTEN	p.Arg233Ter (c.697C>T)	Heterozygous	-	PubMed=28683746, PubMed=24042735
MutationSimple	PTEN	p.Pro213Leufs (c.637_638insT) (c.637C>CT)	Heterozygous	-	PubMed=20944090
MutationSimple	PTEN	p.Tyr46His (c.136T>C)	Heterozygous	-	Unknown, PubMed=20944090
MutationSimple	NRAS	p.Ala146Val (c.437C>T)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

9,10

D13S317

9,10,11

D16S539

11,12,13

D18S51

12,13

D19S433

12,13

D21S11

29,32

D2S1338

15,16

D3S1358

13,14,16,17

D5S818

10,11,12

D7S820

10,11,14

D8S1179

12,15

FGA

21,22,23

Penta D

9,10,11

Penta E

15,16

TH01

7,9.3

TPOX

11

vWA

17,20,22

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.

Lord C.J., Ashworth A., Reis-Filho J.S.

Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010).

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

HEC-1 cells.";

Kuramoto H., Hamano M., Imai M.

Hum. Cell 15:81-95(2002).

In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum.

Ohta H., Sakamoto H., Satoh K.

Cancer Lett. 134:111-118(1998).

BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.

Hamelin R.

Cancer Res. 57:300-303(1997).

Establishment and characterization of human endometrial cancer cell lines.

Ohno E., Iida T.

Ann. N. Y. Acad. Sci. 622:402-421(1991).

The results of primary culture of endometrial adenocarcinoma and characterization of its established cell line.

Morisawa T.

Nihon Rinsho Saibo Gakkai Zasshi 26:433-442(1987).

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

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