HEC-6Homo sapiens (Human)Cancer cell line

Also known as: HEC6

🤖 AI SummaryBased on 7 publications

Quick Overview

Human endometrial cancer cell line with pseudo-diploid karyotype and adenocarcinoma features.

Detailed Summary

HEC-6 is a human endometrial cancer cell line established from an adenoacanthoma, showing characteristics of well-differentiated adenocarcinoma. It exhibits a pseudo-diploid karyotype with random chromosomal variations and forms glandular structures in culture. The cell line maintains the original tumor's features, including both epithelial and squamous components, and is transplantable in vivo. HEC-6 demonstrates a population doubling time of 52 hours and is used for studying endometrial cancer biology and therapeutic responses.

Key Characteristics

Pseudo-diploid karyotypeGlandular structure formation in cultureTransplantable in vivoMaintains original tumor features

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2931
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	48
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Endometrial endometrioid adenocarcinoma, variant with squamous differentiation
Lineage	Uterus
Subtype	Uterine Adenosquamous Carcinoma
OncoTree Code	UASC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000984_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	PTEN	p.Glu288fs*3 (c.863delA)	Heterozygous	-	Unknown
MutationSimple	KRAS	p.Val160Ala (c.479T>C)	Heterozygous	-	Unknown
MutationSimple	PIK3CA	p.Cys420_Pro421del (c.1258_1263delTGTCCA)	Heterozygous	-	Unknown
MutationSimple	PIK3CA	p.Arg108His (c.323G>A)	Heterozygous	-	Unknown
MutationSimple	CTNNB1	p.Asp32Val (c.95A>T)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,10,13

D13S317

11,12

D16S539

8,10

D18S51

12,13

D19S433

D21S11

27.2,29

D2S1338

21,23

D3S1358

16,17

D5S818

13,14,15

D7S820

8,9,11,12

D8S1179

9,10,12

FGA

20,21,22

Penta D

Penta E

14,15,17

TH01

6,9,10

TPOX

8,9,10

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.

Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.

Eur. J. Gynaecol. Oncol. 25:55-60(2004).

PubMed

In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum.

Ohta H., Sakamoto H., Satoh K.

Cancer Lett. 134:111-118(1998).

DOI PubMed

Establishment and characterization of human endometrial cancer cell lines.

Ohno E., Iida T.

Ann. N. Y. Acad. Sci. 622:402-421(1991).

DOI PubMed

Establishment and characterization of the cell-line of a human endometrial adenoacanthoma.

Kuramoto H., Hamano M.

Eur. J. Cancer 13:253-259(1977).

DOI PubMed

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

DOI

Web Resources

tcpaportal.org