HMC-1-8Homo sapiens (Human)Cancer cell line
Also known as: HMC18
🤖 AI SummaryBased on 2 publications
Quick Overview
Human mast cell line for research on cancer and immune responses.
Detailed Summary
HMC-1-8 is a human mast cell line derived from a patient with systemic mastocytosis. This cell line is used in research to study the biology of mast cells and their role in immune responses and cancer. It provides a valuable model for investigating the molecular mechanisms underlying mast cell activation and its implications in disease. The cell line is part of the HMC-1 series, which is widely utilized in studies related to mast cell function and pathology.
Research Applications
Cancer researchImmune response studies
Key Characteristics
Human mast cell lineSystemic mastocytosis origin
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2949 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 35 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | asian |
| Subtype Features | basal_B TNBC |
Disease Information
| Disease | Breast carcinoma |
|---|---|
| Lineage | Breast |
| Subtype | Breast Invasive Ductal Carcinoma |
| OncoTree Code | IDC |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000721_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro152Argfs*18 (c.455delC) | Heterozygous | - | from parent cell line OVK18 |
| MutationSimple | KRAS | p.Gly12Val (c.35G>T) | Heterozygous | Acquired | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
7,12
D13S317
8,10
D16S539
9,12
D5S818
9,10
D7S820
11
TH01
7,9
TPOX
8,12
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Specific cytotoxicity of a long-term cultured T-cell clone on human autologous mammary cancer cells.
Sato T., Sato N., Takahashi S., Koshiba H., Kikuchi K.
Cancer Res. 46:4384-4389(1986).
Characterization of two new cancer cell lines derived from human breast tumors.
Okazaki Y., Toda K.
Tumor Res. 22:27-39(1987).