HMY-1Homo sapiens (Human)Cancer cell line
Also known as: HMY1
🤖 AI SummaryBased on 3 publications
Quick Overview
Human melanoma cell line for cancer research and immunotherapy studies.
Detailed Summary
HMY-1 is a human melanoma cell line established from a malignant melanoma patient. It is used in research to study natural killer (NK) cell cytotoxicity and immunotherapy responses. The cell line exhibits characteristics such as spindle-shaped and polygonal cells with dendrites, and it has been utilized in experiments involving BCG, PPD, and PHA immunopotentiators. HMY-1 has been shown to maintain NK cytotoxicity during most of the clinical course of the patient, with variations observed in different experimental conditions. The cell line is also used to assess the effects of immunopotentiators on NK cell activity, providing insights into cancer immunotherapy strategies.
Research Applications
Cancer researchImmunotherapy studiesNatural killer (NK) cell cytotoxicity assessment
Key Characteristics
Spindle-shaped and polygonal cells with dendritesMaintains NK cytotoxicity during clinical courseResponsive to immunopotentiators like BCG, PPD, and PHA
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2950 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Left inguinal lymph node[UBERON:UBERON_0001542] |
Donor Information
| Age | 62 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001522_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
11,13
D16S539
10
D18S51
14,17
D21S11
30,32.2
D3S1358
15
D5S818
12
D7S820
11,14
D8S1179
14
FGA
22
Penta D
14
Penta E
17,20
TH01
6
TPOX
11
vWA
17,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).