IHH-4Homo sapiens (Human)Cancer cell line
Also known as: IHH4
🤖 AI SummaryBased on 5 publications
Quick Overview
IHH-4 is a human thyroid cancer cell line used in cancer research.
Detailed Summary
IHH-4 is a human thyroid cancer cell line derived from an anaplastic thyroid carcinoma. It is utilized in research to study the genetic and molecular characteristics of thyroid cancers, particularly focusing on mutations in the TERT promoter and other key oncogenic drivers. The cell line has been characterized for its chromosomal abnormalities, gene expression profiles, and response to various therapeutic agents. IHH-4 is part of a panel of cell lines used to investigate the progression and treatment of advanced thyroid cancers, including anaplastic and poorly differentiated forms. Its properties make it a valuable model for understanding the mechanisms of tumor development and drug resistance in thyroid cancer.
Research Applications
Genetic characterization of thyroid cancerAnalysis of TERT promoter mutationsInvestigation of BRAF and RAS mutationsStudy of drug resistance mechanismsModel for advanced thyroid cancer research
Key Characteristics
Presence of TERT promoter mutationsMutations in BRAF and RAS genesChromosomal abnormalitiesExpression of specific markers like PCNA and HLA-class 1Resistance to multiple antineoplastic agents
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2960 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Left cervical lymph node[UBERON:UBERON_0002429] |
Donor Information
| Age | 75 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Differentiated thyroid carcinoma |
|---|---|
| Lineage | Thyroid |
| Subtype | Papillary Thyroid Cancer |
| OncoTree Code | THPA |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001528_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| MutationSimple | RAC1 | p.Asp11Glu (c.33C>G) | Heterozygous | - | from parent cell line IHH-4 |
| MutationSimple | EP300 | p.Arg1312Ter (c.3934C>T) | Heterozygous | - | from parent cell line IHH-4 |
| MutationSimple | CRLF2 | p.Trp255Ter (c.765G>A) | Heterozygous | - | from parent cell line IHH-4 |
| MutationSimple | CREBBP | p.Trp592Ter (c.1776G>A) | Heterozygous | - | from parent cell line IHH-4 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
| MutationSimple | AKT1 | p.Glu17Lys (c.49G>A) | Heterozygous | - | from parent cell line IHH-4 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
10,13
D16S539
9,11
D18S51
13,15
D21S11
30,31
D3S1358
16
D5S818
9,13
D7S820
9,10
D8S1179
11,15
FGA
23,24
Penta D
9
Penta E
10,12
TH01
9
TPOX
11
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Fagin J.A., Schweppe R.E.
Clin. Cancer Res. 25:3141-3151(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
Ibrahimpasic T., Ghossein R.A., Fagin J.A.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).