IM95Homo sapiens (Human)Cancer cell line

Also known as: IM-95, Im95

🤖 AI SummaryBased on 8 publications

Quick Overview

IM95 is a human cancer cell line used in research for studying cancer biology and drug development.

Detailed Summary

IM95 is a human cancer cell line derived from a tumor, though the specific tissue of origin and disease type are not specified in the available data. It is utilized in various research applications, including the study of genomic and transcriptomic alterations, cancer-related pathways, and drug sensitivity. The cell line has been involved in studies related to ZAK isoform usage, which is implicated in cancer progression. Additionally, IM95 has been part of research on gene fusions, mutations, and their impact on cancer cell behavior. The cell line's role in understanding cancer mechanisms and therapeutic responses is highlighted through its participation in comprehensive genomic and transcriptomic analyses.

Research Applications

Genomic and transcriptomic analysisCancer biology researchDrug sensitivity studiesZAK isoform researchGene fusion and mutation studies

Key Characteristics

Part of comprehensive cancer cell line studiesInvolved in ZAK isoform expression analysisUsed in studies of cancer-related pathways

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2961
Species	Homo sapiens (Human)
Tissue Source	Stomach[UBERON:UBERON_0000945]

Donor Information

Age	63
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000919_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

10,12

D16S539

9,10

D18S51

14,23,24

D19S433

12,13

D21S11

31,32.2

D2S1338

D3S1358

D5S818

9,11

D7S820

9.3

D8S1179

12,13

FGA

19,21

Penta D

10,12

Penta E

TH01

6,10

TPOX

8,10

vWA

17,18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

DOI PubMed PMC

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Cloning of a cancer cell-producing hepatocyte growth factor, vascular endothelial growth factor, and interleukin-8 from gastric cancer cells.

Iwai M., Matsuda M., Iwai Y.

In Vitro Cell. Dev. Biol. Anim. 39:288-290(2003).

DOI PubMed

Web Resources

tcpaportal.org