KG-1-CHomo sapiens (Human)Cancer cell line

Also known as: KG-1, KG1C, KG-1C

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cell line for cancer research and drug testing

Detailed Summary

KG-1-C is a human cell line derived from a mixed glioma, commonly used in cancer research. It exhibits characteristics of oligodendroglial cells, including the expression of S-100 protein and responsiveness to cyclic AMP. The cell line is utilized in studies related to glial differentiation and neuron-glia interactions. It has been used in investigations of myelin formation and the effects of various compounds on cellular processes. The cell line's properties make it a valuable tool for understanding the biology of glial cells and their role in neurological diseases.

Research Applications

Cancer researchDrug testingGlial differentiation studiesNeuron-glia interaction studiesMyelin formation research

Key Characteristics

Expression of S-100 proteinResponse to cyclic AMPOligodendroglial featuresUsed in glioma studies

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2971
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	13
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Oligodendroglioma
Lineage	CNS/Brain
Subtype	Oligodendroglioma
OncoTree Code	ODG

DepMap Information

Source Type	HSRRB
Source ID	ACH-000126_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

12,13

D13S317

D16S539

D5S818

11,12

D7S820

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

Tomoda H., Yamori T., Tsuruo T.

J. Natl. Cancer Inst. 97:765-777(2005).

DOI PubMed

Characterization of three human oligodendroglial cell lines as a model to study oligodendrocyte injury: morphology and oligodendrocyte-specific gene expression.

Lambrichts I., Raus J., Ameloot M., Stinissen P., Steels P.

J. Neurocytol. 32:25-38(2003).

DOI PubMed

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Establishment of a human single cell clonal line synthesizing nervous tissue specific protein (S-100 protein).

Miyake E.

Fukuoka Igaku Zasshi 76:500-507(1985).

PubMed

Establishment of a human oligodendroglial cell line.";

Miyake E.

Acta Neuropathol. 46:51-55(1979).

DOI PubMed