KMBC-2Homo sapiens (Human)Cancer cell line
Also known as: KMBC2
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cell line for cancer research
Detailed Summary
KMBC-2 is a human cell line used in cancer research. It is derived from a human tumor, though the specific tissue and disease origin are not specified in the available data. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE), which provides genomic and pharmacological data for a wide range of cancer cell lines. This resource is valuable for understanding drug sensitivity and predictive modeling in cancer treatment. The CCLE includes data on gene expression, chromosomal copy number, and mutations, which can be used to identify genetic predictors of drug response. KMBC-2's inclusion in this database suggests it is utilized for studies involving cancer genomics and drug development.
Research Applications
Cancer genomicsDrug sensitivity profilingPredictive modeling
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Genomic and pharmacological data available
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2977 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Bladder carcinoma |
|---|---|
| Lineage | Bladder/Urinary Tract |
| Subtype | Bladder Urothelial Carcinoma |
| OncoTree Code | BLCA |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000862_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg280Thr (c.839G>C) | Heterozygous | - | Unknown, PubMed=12872257 |
| MutationSimple | PTEN | p.Arg130Gly (c.388C>G) | Homozygous | - | Unknown, Unknown, PubMed=28273451 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
8,10
D16S539
9,11
D5S818
10,11
D7S820
12
TH01
8,9
TPOX
8
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Bladder Cancer 4:169-183(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).