KMRC-1Homo sapiens (Human)Cancer cell line

Also known as: KMRC1

🤖 AI SummaryBased on 6 publications

Quick Overview

Human renal cell carcinoma cell line with potential for research in cancer genomics and drug sensitivity.

Detailed Summary

KMRC-1 is a human renal cell carcinoma (RCC) cell line derived from clear cell RCC (ccRCC). It is part of a panel of cell lines used to study the genomic and molecular characteristics of RCC. Research has shown that KMRC-1 exhibits specific genetic alterations, including copy number losses and mutations in key cancer-related genes, which may contribute to its tumorigenic potential. The cell line has been utilized in studies investigating the relationship between genomic profiles and drug sensitivity, as well as in understanding the molecular mechanisms underlying RCC progression. Additionally, KMRC-1 has been included in analyses comparing the genomic similarity of RCC cell lines to primary tumors, highlighting its relevance in cancer research.

Research Applications

Genomic profiling of renal cell carcinomaDrug sensitivity and resistance studiesMolecular mechanisms of RCC progression

Key Characteristics

Copy number alterations in cancer-related genesPotential for studying tumorigenic mechanismsRelevance in cancer genomics research

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2983
Species	Homo sapiens (Human)
Tissue Source	Kidney[UBERON:UBERON_0002113]

Donor Information

Age Category	Adult
Sex	Male

Disease Information

Disease	Clear cell renal carcinoma
Lineage	Kidney
Subtype	Renal Clear Cell Carcinoma
OncoTree Code	CCRCC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000684_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	VHL	p.Phe76del (c.227_229delTCT)	Heterozygous	-	PubMed=31176917

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,10

D13S317

D16S539

9,12

D18S51

D19S433

13,14

D21S11

30,32.1

D2S1338

18,19

D3S1358

D5S818

D7S820

11,12

D8S1179

10,13

FGA

21,22,23

Penta D

9,13

Penta E

TH01

7,8

TPOX

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.

Mimata H., Seto M., Moriyama M.

BMC Cancer 11:523.1-523.10(2011).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC