KMRC-20Homo sapiens (Human)Cancer cell line

Also known as: KMRC20

🤖 AI SummaryBased on 6 publications

Quick Overview

Human renal cell carcinoma cell line with potential for research in cancer genomics and drug sensitivity.

Detailed Summary

KMRC-20 is a human renal cell carcinoma (RCC) cell line derived from kidney tissue. It is utilized in studies focusing on the genomic characteristics of RCC, particularly in understanding the molecular mechanisms underlying clear cell RCC (ccRCC) and its subtypes. Research involving KMRC-20 has contributed to the identification of genetic alterations, such as copy number variations and mutations, which are critical for understanding tumor biology and developing targeted therapies. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its response to various anticancer drugs, providing insights into drug sensitivity and resistance. Additionally, KMRC-20 has been used to investigate the role of specific genes, such as SAV1, in the pathogenesis of high-grade ccRCC, highlighting its importance in cancer research.

Research Applications

Genomic profiling of renal cell carcinomaDrug sensitivity and resistance studiesInvestigation of genetic mutations in ccRCCAnalysis of copy number variations in cancerStudy of SAV1 gene function in tumor progression

Key Characteristics

Part of the CCLE databaseUsed in studies of ccRCC molecular mechanismsRelevant for understanding tumor heterogeneityUtilized in drug response profiling

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2986
Species	Homo sapiens (Human)
Tissue Source	Kidney[UBERON:UBERON_0002113]

Donor Information

Age Category	Unknown
Sex	Unknown

Disease Information

Disease	Clear cell renal carcinoma
Lineage	Kidney
Subtype	Renal Clear Cell Carcinoma
OncoTree Code	CCRCC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000250_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.672+1G>T	Homozygous	Splice donor mutation	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

9,11

D18S51

14,16

D19S433

13,13.2

D21S11

28,30

D2S1338

D3S1358

D5S818

9,11

D7S820

10,11

D8S1179

12,13

FGA

21,22

Penta D

10,13

Penta E

10,16

TH01

7,9

TPOX

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.

Mimata H., Seto M., Moriyama M.

BMC Cancer 11:523.1-523.10(2011).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC