KMS-27Homo sapiens (Human)Cancer cell line

Also known as: Kawasaki Medical School-27, KMS27

🤖 AI SummaryBased on 11 publications

Quick Overview

Human multiple myeloma cell line with known genetic alterations and drug resistance profiles.

Detailed Summary

KMS-27 is a human multiple myeloma cell line derived from a B-cell lineage. It is characterized by specific genetic alterations, including the 1q12-q22 amplification and the t(11;14) translocation, which are associated with disease progression and drug resistance. This cell line has been used in studies to investigate the molecular mechanisms of myeloma, including the role of PDZK1 in drug resistance. KMS-27 is also utilized in research on the effects of hypoxia and growth factor starvation on cell survival and gene expression. The cell line has been shown to exhibit sensitivity to certain chemotherapeutic agents, making it a valuable model for studying treatment responses in multiple myeloma.

Research Applications

Investigation of genetic alterations in multiple myelomaStudy of drug resistance mechanismsAnalysis of hypoxia and growth factor starvation effectsEvaluation of chemotherapeutic agent sensitivity

Key Characteristics

1q12-q22 amplificationt(11;14) translocationPDZK1 overexpressionSensitivity to certain chemotherapeutic agents
Generated on 6/19/2025

Basic Information

Database IDCVCL_2993
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Donor Information

Age52
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseMultiple myeloma
LineageLymphoid
SubtypePlasma Cell Myeloma
OncoTree CodePCM

DepMap Information

Source TypeHSRRB
Source IDACH-000576_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,12
D13S317
10,11
D16S539
11,12
D18S51
14,16
D21S11
30,32.2
D3S1358
16,17
D5S818
10,12
D7S820
11
D8S1179
11,12
FGA
22,23
Penta D
9,12
Penta E
13,18.4
TH01
6,9
TPOX
8
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.

Sirota M., Wiita A.P.

Leukemia 34:2754-2765(2020).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Integrative high-resolution microarray analysis of human myeloma cell lines reveals deregulated miRNA expression associated with allelic imbalances and gene expression profiles.

Todoerti K., Ronchetti D., Lambertenghi-Deliliers G., Neri A.

Genes Chromosomes Cancer 48:521-531(2009).

An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma.

Fabris S., Lambertenghi-Deliliers G., Neri A.

BMC Med. Genomics 1:37.1-37.9(2008).

Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease.

Lambertenghi-Deliliers G., Bertoni F., Neri A.

Genes Chromosomes Cancer 46:226-238(2007).

Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.

Murakami H., Sadahira Y., Sugihara T.

Br. J. Haematol. 127:292-298(2004).

Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.

Taniwaki M., Inazawa J.

Am. J. Pathol. 165:71-81(2004).