KMS-28PEHomo sapiens (Human)Cancer cell line
Also known as: Kawasaki Medical School-28-Pleural Effusion, KMS28PE, KMS-28-PE
🤖 AI SummaryBased on 6 publications
Quick Overview
Human multiple myeloma cell line with B cell origin, used in cancer research.
Detailed Summary
KMS-28PE is a human multiple myeloma cell line derived from a B cell lineage. It is utilized in research to study the molecular mechanisms of multiple myeloma, particularly focusing on genetic alterations and their implications in disease progression. The cell line is noted for its specific characteristics, including the presence of certain translocations and mutations that are relevant to myeloma pathogenesis. Research involving KMS-28PE has contributed to understanding the role of MYC translocations and other genetic abnormalities in the development of multiple myeloma. This cell line is also used to evaluate the efficacy of therapeutic agents and to model the disease in preclinical studies.
Research Applications
Study of multiple myeloma geneticsEvaluation of therapeutic agentsModeling of disease progression
Key Characteristics
B cell originMYC translocationsGenetic abnormalities associated with myeloma
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2995 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 77 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | asian |
Disease Information
| Disease | Multiple myeloma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Plasma Cell Myeloma |
| OncoTree Code | PCM |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001541_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly105Arg (c.313G>C) | Homozygous | - | Unknown |
| MutationSimple | KRAS | p.Gly12Ala (c.35G>C) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
11
D16S539
9,11
D18S51
14,15
D21S11
30
D3S1358
16
D5S818
14
D7S820
8,11
D8S1179
10,11
FGA
20,23
Penta D
9,11
Penta E
12,15
TH01
7,9.3
TPOX
8,9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Sirota M., Wiita A.P.
Leukemia 34:2754-2765(2020).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Characterization of MYC translocations in multiple myeloma cell lines.
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008).
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Stewart A.K., Carpten J.D., Bergsagel P.L.
Cancer Cell 12:131-144(2007).