KONHomo sapiens (Human)Cancer cell line
Also known as: KOS
🤖 AI SummaryBased on 4 publications
Quick Overview
Human oral squamous cell carcinoma cell line with PRTFDC1 silencing and potential for cancer research.
Detailed Summary
The KON cell line is a human oral squamous cell carcinoma cell line derived from a patient with oral cancer. It is characterized by the silencing of the PRTFDC1 gene, which is associated with epigenetic mechanisms such as DNA methylation. This cell line has been used in studies to investigate the role of PRTFDC1 in oral carcinogenesis and its potential as a tumor suppressor. Research on KON has contributed to understanding the molecular mechanisms of oral cancer, including the impact of genetic and epigenetic alterations on tumor development and progression. The cell line is also part of broader studies on cancer cell line diversity and ancestry, highlighting the importance of considering genetic background in cancer research.
Research Applications
Investigation of PRTFDC1 gene silencing in oral cancerStudy of epigenetic mechanisms in tumor developmentAnalysis of genetic and epigenetic alterations in cancer progressionResearch on cancer cell line diversity and ancestry
Key Characteristics
Silencing of PRTFDC1 geneEpigenetic regulation via DNA methylationRelevance to oral squamous cell carcinomaPart of broader cancer research initiatives
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_3001 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Cervical lymph node[UBERON:UBERON_0002429] |
Donor Information
| Age | 76 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001542_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
11,12
D16S539
9,11
D18S51
14,15
D21S11
29,30
D3S1358
16
D5S818
11,13
D7S820
8,11
D8S1179
10,14
FGA
22,24
Penta D
9
Penta E
12,16
TH01
7,9
TPOX
9,11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Kozaki K.-i., Amagasa T., Inazawa J.
Oncogene 26:7921-7932(2007).
Establishment and characterization of a human oral squamous cell carcinoma cell line (KON).
Ohara M., Yasui A., Ishikawa T.
Nihon Koku Geka Gakkai Zasshi 41:19-25(1995).