Back to Cell Types

KP-2Homo sapiens (Human)Cancer cell line

Also known as: KP2

🤖 AI SummaryBased on 8 publications

Quick Overview

Human pancreatic cancer cell line with metastatic potential

Detailed Summary

KP-2 is a human pancreatic cancer cell line established from a primary tumor biopsy. It exhibits characteristics of moderately differentiated tubular adenocarcinoma and has been used in studies of pancreatic cancer metastasis. The cell line shows distinct metabolic profiles compared to other pancreatic cancer cell lines, with potential implications for therapeutic targeting. KP-2 has been utilized in xenograft models to study tumor growth and drug response, providing insights into pancreatic cancer biology and treatment strategies.

Research Applications

Metastasis studiesXenograft modelsMetabolic profilingDrug response analysis

Key Characteristics

Moderately differentiated tubular adenocarcinomaMetastatic potentialDistinct metabolic profileXenograft tumor formation

Generated on 6/19/2025

Basic Information

Database ID	CVCL_3004
Species	Homo sapiens (Human)
Tissue Source	Pancreas[UBERON:UBERON_0001264]

Donor Information

Age	65
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Pancreatic carcinoma
Lineage	Pancreas
Subtype	Pancreatic Adenocarcinoma
OncoTree Code	PAAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000281_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ala161Asp (c.482C>A)	Unspecified	-	PubMed=16541312
MutationSimple	SMAD4	p.Asp415Glufs*20 (c.1245_1248delCAGA)	Heterozygous	-	from parent cell line KP-2
MutationSimple	KRAS	p.Gly12Arg (c.34G>C)	Unspecified	-	PubMed=26124327

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

8,13

D16S539

9,10

D18S51

14

D21S11

31,32.2

D3S1358

15,16

D5S818

9,13

D7S820

10,12

D8S1179

14,17

FGA

20

Penta D

9,12

Penta E

12,13,15

TH01

9

TPOX

8,11

vWA

14

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.

Shimazoe T., Nawata H., Kono A.

Oncol. Rep. 1:1223-1227(1994).

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

Shiratori K., Hirohashi S., Inazawa J., Imoto I.

Cancer Sci. 99:986-994(2008).

Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice.

Ikeda Y., Ezaki M., Hayashi I., Yasuda D., Nakayama K., Kono A.

Jpn. J. Cancer Res. 81:987-993(1990).

Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.

Saeger H.-D.

Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).