Lu-99Homo sapiens (Human)Cancer cell line

Also known as: C-Lu99, LU99, Lu99, Lu 99, LU-99

🤖 AI SummaryBased on 7 publications

Quick Overview

Lu-99 is a human lung cancer cell line with EGFR mutations and potential for drug sensitivity studies.

Detailed Summary

Lu-99 is a human lung cancer cell line derived from a giant cell carcinoma. It is known for harboring EGFR mutations, which are significant in the context of targeted therapies. The cell line has been used in studies examining the genetic heterogeneity of EGFR mutations and their implications for drug response. Research on Lu-99 has contributed to understanding the mechanisms of resistance and sensitivity to tyrosine kinase inhibitors like gefitinib. Additionally, it has been part of studies investigating the role of DCC gene expression and its association with cancer progression. The cell line's characteristics make it a valuable tool for studying lung cancer biology and therapeutic strategies.

Research Applications

EGFR mutation analysisDrug sensitivity studiesCancer biology researchGenetic heterogeneity studies

Key Characteristics

EGFR mutationsPotential for targeted therapy researchUsed in studies on drug resistancePart of DCC gene expression investigations

Generated on 6/19/2025

Basic Information

Database ID	CVCL_3015
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	63
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Lung giant cell carcinoma
Lineage	Lung
Subtype	Giant Cell Carcinoma of the Lung
OncoTree Code	GCLC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000444_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Cys (c.34G>T)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,15

D13S317

10,11

D16S539

D5S818

D7S820

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.

Kasai F., Fukushima M., Miyagi Y., Nakamura Y.

Hum. Cell 37:944-950(2024).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.

Igishi T., Burioka N., Nanba E., Shimizu E.

Cancer Biol. Ther. 13:369-378(2012).

DOI PubMed

Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.

Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.

Cancer Res. 65:7276-7282(2005).

DOI PubMed

Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.

Hayashi S., Aozasa K., Kawase I.

Oncogene 22:674-687(2003).

DOI PubMed

Mutation and expression of the DCC gene in human lung cancer.";

Yokota J.

Neoplasia 2:300-305(2000).

DOI PubMed PMC

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Giant cell carcinomas of the lung producing colony-stimulating factor in vitro and in vivo.

Ogura T., Gamou S., Shimizu N.

Jpn. J. Cancer Res. 76:967-976(1985).

DOI PubMed