MTAHomo sapiens (Human)Cancer cell line

The MTA cell line is derived from a patient with aggressive NK-like T-cell leukemia/lymphoma. It is part of a study examining ATR gene alterations in nasal NK/T-cell lymphoma (NKTCL) and chronic active Epstein-Barr virus (CAEBV) infections. Research indicates that MTA exhibits wild-type ATR gene status, but it is associated with defects in DNA repair mechanisms, including delayed repair of DNA double-strand breaks and single-strand breaks following ionizing radiation and ultraviolet exposure. These findings suggest a potential role for ATR gene alterations in the pathogenesis of NKTCL, although MTA itself does not show ATR mutations. The cell line is used in studies related to DNA damage response and chromosomal instability in lymphoproliferative disorders.