MYHomo sapiens (Human)Cancer cell line

The MY cell line is a human mononuclear cell line that has been studied in the context of cancer research. It was identified in a genome-wide screen for microdeletions that revealed disruptions in polarity complex genes across various human cancers. Specifically, the MY cell line was found to have homozygous intragenic microdeletions involving the PARD3 gene, which is associated with apical-basal cell polarity complexes. These deletions were observed in squamous carcinomas and glioblastomas, suggesting a potential role in tumorigenesis. Reconstituting PARD3 expression in these cell lines has been shown to restore tight junctions and inhibit contact-dependent proliferation, highlighting the importance of PARD3 in maintaining cell polarity and preventing uncontrolled cell growth. The MY cell line provides a valuable model for studying the genetic alterations and molecular mechanisms underlying cancer development and progression.