NCO2Homo sapiens (Human)Cancer cell line
Also known as: NC-02, NCO-2, NC02
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cancer cell line with unknown tissue and disease origins.
Detailed Summary
The NCO2 cell line is a human-derived cancer cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized in genomic and pharmacological studies. Research on NCO2 focuses on understanding its genetic and molecular profiles to identify potential therapeutic targets and drug sensitivities. The cell line's role in cancer research is primarily in the context of genomic and pharmacological profiling, contributing to the broader understanding of cancer biology and drug response mechanisms.
Research Applications
Genomic profilingPharmacological profilingDrug sensitivity analysis
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of cancer biology and drug response
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_3043 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 35 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Subtype Features | BCR-ABL1 positive |
Disease Information
| Disease | Chronic myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Chronic Myeloid Leukemia, BCR-ABL1+ |
| OncoTree Code | CMLBCRABL1 |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000076_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly266Arg (c.796G>C) | Unspecified | - | PubMed=22361929 |
| Gene fusion | ABL1 | BCR-ABL1, BCR-ABL | - | BCR exon 1 fused to ABL1 exon 2 | PubMed=10576511, PubMed=10071072, PubMed=8751477 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13
D13S317
11
D16S539
11
D5S818
12
D7S820
13
TH01
6
TPOX
11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Aizawa Y., Ueda R., Seto M.
Jpn. J. Cancer Res. 89:712-718(1998).
Up-regulation of transferrin receptor gene expression by granulocyte colony-stimulating factor in human myeloid leukemia cells.
Morishima Y., Saito H.
Cancer Res. 50:7955-7961(1990).