NOZHomo sapiens (Human)Cancer cell line
Also known as: NOZC-1, NOZAWA, NO2
🤖 AI SummaryBased on 2 publications
Quick Overview
NOZ is a human gallbladder cancer cell line used in cancer research.
Detailed Summary
NOZ is a human gallbladder cancer cell line that has been characterized in research for its genetic and morphological responses to chemotherapy agents. It is used in studies examining the effects of drugs like epirubicin and doxorubicin, showing distinct cytocidal effects and morphological changes. The cell line is also part of comprehensive RNA sequencing studies, providing insights into mutations and gene expression profiles relevant to hepatobiliary cancers. These studies highlight its utility in understanding cancer mechanisms and drug responses.
Research Applications
Cancer researchDrug response studiesGenetic mutation analysisGene expression profiling
Key Characteristics
Used in chemotherapy effect studiesCharacterized for RNA sequencingMorphological changes observed with drug treatments
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_3079 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 48 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Carcinoma of gallbladder and extrahepatic biliary tract |
|---|---|
| Lineage | Biliary Tract |
| Subtype | Gallbladder Adenocarcinoma, NOS |
| OncoTree Code | GBAD |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001607_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln331Ter (c.991C>T) | Homozygous | - | PubMed=29970484, PubMed=15287027 |
| MutationSimple | KRAS | p.Gly12Val (c.35G>T) | Heterozygous | Acquired | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,13
D13S317
8,12
D16S539
9,11
D18S51
12
D21S11
30,31
D3S1358
15,17
D5S818
11,13
D7S820
10,11
D8S1179
9,14
FGA
17
Penta D
11,13
Penta E
12,17
TH01
7,9
TPOX
8,11
vWA
19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
Vazquez F., Getz G., Bardeesy N.M.
bioRxiv 2024:07.04.601970-07.04.601970(2024).
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.
Cancers (Basel) 12:2510.1-2510.14(2020).
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.
Biol. Res. 53:13.1-13.17(2020).
Establishment and characterization of a human gall bladder carcinoma cell line NOZ.
Homma S., Hasumura S., Nagamori S., Kameda H.
Hum. Cell 1:95-97(1988).
Combination therapy of hyperthermia and other methods in liver and bile tract cancers -- evaluation of these methods using cancer cell lines in vitro.
Shimizu K., Niiya M., Kameda H.
Gan To Kagaku Ryoho 16:1905-1912(1989).
Morphological changes in human gall bladder carcinoma cell line-NOZ due to epirubicin and doxorubicin.
Hasumura S., Nagamori S., Toda G.
Med. Electron Microsc. 27:175-177(1994).