OCUG-1Homo sapiens (Human)Cancer cell line
Also known as: Osaka City University Gallbladder-1, OCUG1
🤖 AI SummaryBased on 3 publications
Quick Overview
OCUG-1 is a human gallbladder carcinoma cell line established from peritoneal effusion, known for producing TA-4 and exhibiting...
Detailed Summary
OCUG-1 is a human gallbladder carcinoma cell line derived from peritoneal effusion of a patient with malignant gallbladder carcinoma. It is characterized by its ability to produce TA-4, a tumor marker associated with squamous cell carcinoma. The cell line exhibits transitional features between adenocarcinoma and squamous cell carcinoma, as suggested by its histological and molecular characteristics. OCUG-1 cells grow in clusters and have a population doubling time of approximately 47.1 hours. They are aneuploid with a broad range of chromosome numbers (52-139) and show high levels of TA-4 in culture. When injected into nude mice, OCUG-1 cells form poorly differentiated adenocarcinomas, confirming their tumorigenic potential. This cell line is valuable for studying the biological nature of gallbladder carcinoma and the relationship between TA-4 expression and squamatization.
Research Applications
Study of TA-4 expression and its role in squamatizationInvestigation of transitional characteristics between adenocarcinoma and squamous cell carcinomaTumorigenicity studies in nude miceAnalysis of aneuploidy and chromosomal instability
Key Characteristics
Produces TA-4 tumor markerTransitional features between adenocarcinoma and squamous cell carcinomaAneuploid with broad chromosome range (52-139)Tumorigenic in nude micePopulation doubling time of ~47.1 hours
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_3083 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peritoneal effusion[UBERON:UBERON_0001268] |
Donor Information
| Age | 43 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Carcinoma of gallbladder and extrahepatic biliary tract |
|---|---|
| Lineage | Biliary Tract |
| Subtype | Gallbladder Adenocarcinoma, NOS |
| OncoTree Code | GBAD |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001619_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg267Trp (c.799C>T) | Unspecified | Somatic mutation acquired during proliferation | PubMed=28445466 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
8,11
D16S539
9,13
D18S51
16,19
D21S11
28,29
D3S1358
15
D5S818
10,12
D7S820
10,11
D8S1179
14,15
FGA
21,24
Penta D
9
Penta E
5,20
TH01
7,9.3
TPOX
8,11
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
Vazquez F., Getz G., Bardeesy N.M.
bioRxiv 2024:07.04.601970-07.04.601970(2024).
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.
Cancers (Basel) 12:2510.1-2510.14(2020).
Establishment and characterization of a new human gallbladder carcinoma cell line (OCUG-1) producing TA-4.
Nishiguchi Y., Hasuma T., Sowa M.
Int. J. Oncol. 10:1251-1255(1997).