OCUM-1Homo sapiens (Human)Cancer cell line

Also known as: Osaka City University Medical school-1, OCUM1

🤖 AI SummaryBased on 10 publications

Quick Overview

OCUM-1 is a human gastric cancer cell line with specific genetic mutations and potential for cancer research.

Detailed Summary

OCUM-1 is a human gastric cancer cell line derived from a scirrhous-type gastric carcinoma. It is characterized by the presence of the MAP2K1(Q56P) mutation, which plays a critical role in its transformation and proliferation. This cell line has been used in studies to identify activating mutations in the MAP2K1 gene, which are associated with various epithelial tumors. The OCUM-1 cell line is also noted for its dependency on MAP2K1 activity for growth, making it a valuable model for studying the RAS-MAPK signaling pathway in cancer. Research on OCUM-1 has contributed to understanding the role of MAP2K1 mutations in tumorigenesis and has implications for targeted therapy development.

Research Applications

Identification of MAP2K1 mutationsStudy of RAS-MAPK signaling pathwayDevelopment of targeted therapies

Key Characteristics

Presence of MAP2K1(Q56P) mutationDependency on MAP2K1 activity for growthUse in cancer research and drug development

Generated on 6/19/2025

Basic Information

Database ID	CVCL_3084
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	38
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Gastric signet ring cell adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Diffuse Type Stomach Adenocarcinoma
OncoTree Code	DSTAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000247_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	MAP2K1	p.Gln56Pro (c.167A>C)	Hemizygous	-	PubMed=22327936

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

10,11

D16S539

D18S51

12,13

D21S11

D3S1358

D5S818

9,10

D7S820

D8S1179

11,12

FGA

19,23

Penta D

12,13

Penta E

12,19

TH01

TPOX

8,11

vWA

14,16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

DOI PubMed PMC

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Oncogenic MAP2K1 mutations in human epithelial tumors.";

Fukumura K., Ando M., Kawazu M., Yamashita Y., Mano H.

Carcinogenesis 33:956-961(2012).

DOI PubMed

Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells.

Hirakawa K., Oka M., Nakamura K.

Anticancer Res. 30:4459-4465(2010).

PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

DOI PubMed PMC

Establishment and characterization of a new gastric cancer cell line (OCUM-1), derived from Borrmann type IV tumor.

Kubo T.

Nihon Geka Gakkai Zasshi 92:1451-1460(1991).

PubMed

Gastric tumor cell lines.";

Sekiguchi M., Suzuki T.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).

DOI