OSC-19Homo sapiens (Human)Cancer cell line
Also known as: Osc19, OSC19
Quick Overview
Human head and neck squamous cell carcinoma cell line for cancer research.
Detailed Summary
Basic Information
| Database ID | CVCL_3086 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Cervical lymph node[UBERON:UBERON_0002429] |
Donor Information
| Age | 61 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001625_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Lys164Ter (c.490A>T) | Homozygous | - | from parent cell line SNU-387 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
Ito Y., Myers J.N., Oridate N.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients.
Yamaguchi A., Hiratsuka H., Sato N.
J. Transl. Med. 7:1.1-1.11(2009).
Interferon-alpha and interferon-gamma augment apoptosis in oral carcinoma cells treated with Shiga toxin 2 (Stx2).
Fujii N.
Tumor Res. 35:25-33(2000).
Establishment and characterization of OSC-19 cell line in serum- and protein-free culture.
Yokoi T., Homma H., Odajima T.
Tumor Res. 24:57-73(1989).
Establishment and characterization of a human cell line derived from a squamous cell carcinoma of the tongue.
Yokoi T., Yamaguchi A., Odajima T., Furukawa K.
Tumor Res. 23:43-57(1989).