OSC-20Homo sapiens (Human)Cancer cell line

Also known as: OSC20

🤖 AI SummaryBased on 6 publications

Quick Overview

Human squamous cell carcinoma cell line derived from tongue cancer, used in cancer immunotherapy research.

Detailed Summary

OSC-20 is a human squamous cell carcinoma (SCC) cell line established from a tongue cancer patient. It is widely used in cancer research, particularly in studies involving T-cell immunotherapy and antigen recognition. The cell line expresses HLA-DR8 and is utilized to investigate CD4+ T-cell responses against tumor antigens. Research has identified specific peptides, such as the α-enolase-derived peptide, that are recognized by CD4+ T cells, highlighting its role in understanding tumor-immune interactions. OSC-20 is also used to study the genetic and molecular mechanisms of cancer progression and immune evasion.

Research Applications

Immunotherapy researchT-cell antigen recognitionCancer immunologyTumor-immune interactions

Key Characteristics

HLA-DR8 expressionCD4+ T-cell recognitionα-enolase-derived peptide recognition

Generated on 6/19/2025

Basic Information

Database ID	CVCL_3087
Species	Homo sapiens (Human)
Tissue Source	Cervical lymph node[UBERON:UBERON_0002429]

Donor Information

Age	59
Age Category	Adult
Sex	Female

Disease Information

Disease	Squamous cell carcinoma of the oral tongue
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	JCRB
Source ID	ACH-001626_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg249Ser (c.747G>T)	Unspecified	-	PubMed=11799138, CelloPub=CLPUB00439
MutationSimple	PIK3CA	p.His1048Arg (c.3143A>G)	Heterozygous	-	Unknown, Unknown
MutationSimple	CDKN2A	p.Pro81Leu (c.242C>T)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

12,13

D13S317

D16S539

9,13

D18S51

D21S11

29,32.2

D3S1358

D5S818

D7S820

D8S1179

12,14

FGA

Penta D

9,12

Penta E

14,16

TH01

9,9.3

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients.

Yamaguchi A., Hiratsuka H., Sato N.

J. Transl. Med. 7:1.1-1.11(2009).

DOI PubMed PMC

Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells.

Hamuro J., Torigoe T., Takahashi N., Kohama G.-i., Ikeda H., Sato N.

Jpn. J. Cancer Res. 93:917-924(2002).

DOI PubMed PMC

Cytotoxicity of histocompatibility leukocyte antigen-DR8-restricted CD4 killer T cells against human autologous squamous cell carcinoma.

Yamaguchi A., Yagihashi A., Kikuchi K.

Jpn. J. Cancer Res. 88:191-197(1997).

DOI PubMed PMC

Interferon-alpha and interferon-gamma augment apoptosis in oral carcinoma cells treated with Shiga toxin 2 (Stx2).

Fujii N.

Tumor Res. 35:25-33(2000).

DOI

Some properties of a newly established human cell line from a oral squamous carcinoma.

Kohama G.-i., Mochizuki Y.

Tumor Res. 25:93-103(1990).

DOI