OUMS-23Homo sapiens (Human)Cancer cell line

Also known as: Okayama University Medical School-23, OUMS23

🤖 AI SummaryBased on 8 publications

Quick Overview

Human colon cancer cell line derived from a patient with familial adenomatous polyposis.

Detailed Summary

OUMS-23 is a human colon cancer cell line established from metastatic pericardial fluid of a male patient with familial adenomatous polyposis (FAP). The cell line exhibits epithelial characteristics, forming domes and expressing markers such as carcinoembryonic antigen (CEA) and placenta-like alkaline phosphatase. It demonstrates tumorigenic potential in nude mice, forming differentiated adenocarcinoma. OUMS-23 shows distinct chromosomal abnormalities and lacks mutations in the APC gene, but exhibits reduced APC gene expression. It is used in studies of colon carcinogenesis and tumor suppressor gene function.

Research Applications

Cancer biologyTumor suppressor gene analysisColon carcinogenesisDrug screening

Key Characteristics

Expresses CEAPlacenta-like alkaline phosphataseTumorigenic in nude miceChromosomal abnormalities

Generated on 6/19/2025

Basic Information

Database ID	CVCL_3088
Species	Homo sapiens (Human)
Tissue Source	Pericardial effusion[UBERON:UBERON_0002409]

Donor Information

Age	37
Age Category	Adult
Sex	Male

Disease Information

Disease	Familial adenomatous polyposis
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000296_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr234Cys (c.701A>G)	Heterozygous	-	PubMed=27822414
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590
MutationSimple	APC	p.Thr1556fs*3 (c.4660_4661insA) (E1554fs)	Heterozygous	-	from parent cell line Panc 04.03
MutationSimple	APC	p.Arg657fs (c.1969_1970delAG)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

D21S11

28,30

D3S1358

16,17

D5S818

D7S820

10,13

D8S1179

13,16

FGA

23.2

Penta D

9,12

Penta E

5,9

TH01

7,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

DOI PubMed

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.

Fukaya K.-i., Ishioka C., Namba M.

Acta Med. Okayama 51:261-265(1997).

DOI PubMed

Establishment and characterization of a human colon cancer cell line, OUMS-23, from a patient with familial adenomatous polyposis.

Mori M., Namba M.

J. Cancer Res. Clin. Oncol. 122:95-101(1996).

DOI PubMed

The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.

Ohashi R., Namba M.

Tissue Cult. Res. Commun. 16:173-178(1997).

DOI