OUMS-27Homo sapiens (Human)Cancer cell line
Also known as: Okayama University Medical School-27, OUMS27
🤖 AI SummaryBased on 4 publications
Quick Overview
OUMS-27 is a chondrosarcoma cell line with IDH1/IDH2 mutations, used in cancer research.
Detailed Summary
OUMS-27 is a chondrosarcoma cell line that has been studied for its genetic characteristics, particularly in relation to IDH1 and IDH2 mutations. These mutations are associated with various cartilage tumors and have implications for understanding tumor biology and potential therapeutic targets. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies examining drug sensitivity and genetic diversity. Research on OUMS-27 contributes to the understanding of how IDH mutations influence tumor development and response to treatment. It is also part of efforts to create more representative models for cancer research, especially in addressing disparities in cancer outcomes across different populations.
Research Applications
IDH1/IDH2 mutation analysisCancer researchDrug sensitivity studiesGenetic diversity studies
Key Characteristics
IDH1/IDH2 mutationsChondrosarcoma originPart of CCLEUsed in cancer disparity research
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_3090 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone, left proximal humerus[UBERON:UBERON_0004411] |
Donor Information
| Age | 65 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Chondrosarcoma |
|---|---|
| Lineage | Bone |
| Subtype | Chondrosarcoma |
| OncoTree Code | CHS |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-001150_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | IDH2 | - | - | - | PubMed=22057234 |
| MutationNone reported | IDH1 | - | - | - | PubMed=19435942 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
12
D16S539
14
D5S818
10,11
D7S820
10,12
TH01
9
TPOX
11
vWA
14
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Kurek K.C., Szuhai K., French P.J., Bovee J.V.M.G.
Nat. Genet. 43:1256-1261(2011).
A new human chondrosarcoma cell line (OUMS-27) that maintains chondrocytic differentiation.
Namba M.
Int. J. Cancer 77:854-859(1998).
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Fukaya K.-i., Ishioka C., Namba M.
Acta Med. Okayama 51:261-265(1997).
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Ohashi R., Namba M.
Tissue Cult. Res. Commun. 16:173-178(1997).