OVISEHomo sapiens (Human)Cancer cell line

🤖 AI SummaryBased on 13 publications

Quick Overview

OVISE is a human ovarian cancer cell line used in research for studying high-grade serous ovarian cancer.

Detailed Summary

OVISE is a human ovarian cancer cell line derived from high-grade serous ovarian cancer, a common and aggressive subtype of ovarian cancer. It is widely used in cancer research to study the molecular mechanisms and genetic alterations associated with this disease. The cell line has been characterized in multiple studies for its genomic profile, including mutations in key genes such as TP53, PIK3CA, and others. Research on OVISE has contributed to understanding the complexities of ovarian cancer biology and has been utilized in drug sensitivity studies and functional genomics analyses. Its genomic and proteomic data are part of large-scale cancer research initiatives, providing valuable insights into tumor heterogeneity and therapeutic responses.

Research Applications

Genomic profilingProteomic analysisDrug sensitivity studiesFunctional genomicsTumor heterogeneity research

Key Characteristics

High-grade serous ovarian cancerTP53 mutationsPIK3CA mutationsGenomic instabilityExpression of cancer-related genes
Generated on 6/19/2025

Basic Information

Database IDCVCL_3116
SpeciesHomo sapiens (Human)
Tissue SourcePelvis, innominate bone[UBERON:UBERON_0001272]

Donor Information

Age40
Age CategoryAdult
SexFemale
Raceasian

Disease Information

DiseaseClear cell adenocarcinoma of the ovary
LineageOvary/Fallopian Tube
SubtypeClear Cell Ovarian Cancer
OncoTree CodeCCOV

DepMap Information

Source TypeHSRRB
Source IDACH-000527_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimplePIK3CAp.Cys420Arg (c.1258T>C)Heterozygous-from parent cell line JIMT-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
9,11
D13S317
11,12
D16S539
9
D18S51
19
D21S11
28,30
D3S1358
14,15
D5S818
10
D7S820
11,12
D8S1179
15,16
FGA
19,23
Penta D
9,11
Penta E
14
TH01
9,9.3
TPOX
8
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.

Velculescu V.E., Scharpf R.B.

Cell Rep. 25:2617-2633(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.

Nat. Commun. 7:12645.1-12645.14(2016).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Data for identification of GPI-anchored peptides and omega-sites in cancer cell lines.

Masuishi Y., Kimura Y., Arakawa N., Hirano H.

Data Brief 7:1302-1305(2016).

Identification of glycosylphosphatidylinositol-anchored proteins and omega-sites using TiO2-based affinity purification followed by hydrogen fluoride treatment.

Masuishi Y., Kimura Y., Arakawa N., Hirano H.

J. Proteomics 139:77-83(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Itamochi H., Bodenmiller B., Erler J.T., Turk B.E., Linding R.

Cell 163:202-217(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Type-specific cell line models for type-specific ovarian cancer research.

Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.

PLoS ONE 8:E72162-E72162(2013).

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.

Miyazaki K.

Hum. Pathol. 43:2197-2206(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.";

Anderson M.L., Matzuk M.M.

Mol. Endocrinol. 24:447-463(2010).

Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.

Hirohashi S., Inazawa J., Imoto I.

Cancer Res. 67:7095-7105(2007).

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

Edwards P.A.W., Caldas C.

Carcinogenesis 26:923-930(2005).

Cyclophosphamide and 5-fluorouracil act synergistically in ovarian clear cell adenocarcinoma cells.

Hirahara F., Shirotake S.

Cancer Lett. 162:39-48(2001).

Complexity of expression of the intermediate filaments of six new human ovarian carcinoma cell lines: new expression of cytokeratin 20.

Kitamura H., Minaguchi H.

Br. J. Cancer 76:829-835(1997).

Establishment and characterization of two human ovarian clear cell adenocarcinoma lines from metastatic lesions with different properties.

Minaguchi H.

Gynecol. Oncol. 57:33-46(1995).

Establishment and characterization of human ovarian clear cell carcinoma cell line, OVISE.

Nakazawa T., Gorai I., Doi C., Hirahara F., Minaguchi H.

Nihon Rinsho Saibo Gakkai Zasshi 31:966-972(1992).

Web Resources