RERF-GC-1BHomo sapiens (Human)Cancer cell line

Also known as: Radiation Effects Research Foundation-Gastric Cancer-1B, RerfGC1B, RERFGC1B

🤖 AI SummaryBased on 8 publications

Quick Overview

Human gastric cancer cell line with ZAK isoform upregulation and potential for drug sensitivity studies.

Detailed Summary

RERF-GC-1B is a human gastric cancer cell line derived from a primary tumor, characterized by the preferential upregulation of the ZAK kinase isoform TV1. This cell line exhibits significant alterations in gene expression and copy number, making it a valuable model for studying gastric cancer biology and therapeutic responses. The overexpression of ZAK TV1 has been linked to activation of multiple cancer-related signaling pathways, suggesting its potential as a therapeutic target. Additionally, RERF-GC-1B shows sensitivity to targeted therapies, making it a useful tool for preclinical drug development and personalized medicine research.

Research Applications

Gastric cancer biologyZAK kinase isoform studiesDrug sensitivity profilingTargeted therapy development

Key Characteristics

Preferential upregulation of ZAK TV1Altered gene expression and copy numberSensitivity to targeted therapies

Generated on 6/19/2025

Basic Information

Database ID	CVCL_3152
Species	Homo sapiens (Human)
Tissue Source	Pyloric lymph node[UBERON:UBERON_0015866]

Donor Information

Age	41
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000144_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

12,13

D13S317

D16S539

D18S51

D21S11

29,30

D3S1358

15,16

D5S818

10,12

D7S820

10,13

D8S1179

15,17

FGA

Penta D

8,11

Penta E

12,24

TH01

TPOX

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

DOI PubMed PMC