T.THomo sapiens (Human)Cancer cell line

Also known as: TT, tdott, T. T, T_T_, T-T

🤖 AI SummaryBased on 5 publications

Quick Overview

Human cell line for cancer research

Detailed Summary

The T.T cell line is a human-derived cell line used in cancer research. It is characterized by its origin from a human tissue, though the specific tissue type is not specified. The cell line is associated with cancer, but the exact disease type is not detailed. Its cell type is unspecified, and the description provided is limited. Despite these gaps, the T.T cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in studies related to drug sensitivity and genetic profiling. It is one of the many cell lines used in comprehensive cancer research efforts to understand genetic diversity and its implications in cancer treatment.

Research Applications

Cancer researchDrug sensitivity studiesGenetic profiling

Key Characteristics

Human-derivedPart of CCLEUsed in drug sensitivity and genetic studies

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3174
Species	Homo sapiens (Human)
Tissue Source	Bone, jaw, mandible[UBERON:UBERON_0001684]

Donor Information

Age	67
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000561_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.His214Arg (c.641A>G)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,13

D13S317

D16S539

9,11

D18S51

13,17

D19S433

14,15

D21S11

D2S1338

D3S1358

D5S818

8,10

D7S820

D8S1179

15,16

FGA

Penta D

Penta E

16,18

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

A case of esophageal carcinoma metastatic to the mandible and characterization of two cell lines (T-T and T-Tn) established from the oral tumor.

Sato K.-i.

Nihon Koku Geka Gakkai Zasshi 36:307-316(1990).

DOI