TASK1Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 3 publications
Quick Overview
Human cell line with potential for cancer research.
Detailed Summary
The TASK1 cell line is derived from a primitive neuroectodermal tumor (PNET) and exhibits characteristics of Ewing's family of tumors. It shows high expression of the MIC2 gene product, chromosomal translocations, and tumorigenicity in nude mice. This cell line is useful for studying the molecular mechanisms and therapeutic strategies related to Ewing's sarcoma and PNET.
Research Applications
Cancer researchMolecular mechanisms of Ewing's sarcomaTherapeutic strategies for PNET
Key Characteristics
High expression of MIC2 gene productChromosomal translocation t(11;22)Tumorigenicity in nude mice
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3177 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Chest wall[UBERON:UBERON_0016435] |
Donor Information
| Age | 21 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Peripheral primitive neuroectodermal tumor |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Primitive Neuroectodermal Tumor |
| OncoTree Code | PNET |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001670_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | EWSR1 | EWSR1-FLI1, EWS-FLI1 | - | Type 1 fusion | PubMed=15150091 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8
D16S539
12
D18S51
14
D21S11
30,31
D3S1358
18
D5S818
13
D7S820
12
D8S1179
10
FGA
23
Penta D
9,11
Penta E
5,11
TH01
9
TPOX
11
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).