ZEM2SDanio rerio (Zebrafish)Spontaneously immortalized cell line

ZEM2S is a zebrafish (Danio rerio) cell line derived from embryos, characterized as fibroblast-like. It is utilized in environmental toxicology and ecotoxicology research, particularly for evaluating the effects of pollutants on fish cells. The cell line is capable of being maintained in various media supplemented with fetal bovine serum, and it has been used to study xenobiotic metabolism and cytotoxicity. ZEM2S has been employed in assays to detect the presence of dioxin-like compounds and other environmental contaminants, contributing to the understanding of their biological impacts. Additionally, it has been used in studies involving the induction of cytochrome P4501A enzyme activity, which is relevant to the metabolism of toxicants. The cell line's utility extends to the development of bioassays for assessing the toxicity of environmental samples, including water and sediment.