ZFLDanio rerio (Zebrafish)Spontaneously immortalized cell line
Also known as: Zebrafish Liver Epithelium, ZLE, ZebraFish Liver, ZF-L
🤖 AI SummaryBased on 4 publications
Quick Overview
Zebrafish liver cell line for immune and toxicology studies
Detailed Summary
The ZFL cell line, derived from adult zebrafish liver, is an epithelial cell line used in immune response and toxicology research. It exhibits characteristics of liver parenchymal cells, including expression of enzymes like alanine aminotransferase and glucose-6-phosphatase. ZFL cells respond to immune stimuli such as Poly(I:C), showing activation of antiviral pathways and upregulation of genes like TLR3 and IFIH1. They are also utilized in taurine biosynthesis studies, demonstrating the ability to synthesize taurine and regulate its transport. The cell line is valuable for studying xenobiotic metabolism and has been adapted to serum-free conditions for controlled experiments.
Research Applications
Immune response studiesToxicologyTaurine biosynthesisXenobiotic metabolismViral infection research
Key Characteristics
Expresses liver-specific enzymesResponds to immune stimuliCapable of taurine synthesisAdaptable to serum-free conditions
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3276 |
|---|---|
| Species | Danio rerio (Zebrafish) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
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Disease Information
DepMap Information
Publications
Taurine biosynthesis in a fish liver cell line (ZFL) adapted to a serum-free medium.
Liu C.-L., Watson A.M., Place A.R., Jagus R.
Mar. Drugs 15:147.1-147.15(2017).
Zebrafish liver (ZFL) cells are able to mount an anti-viral response after stimulation with poly (I:C).
Ruyra A., Torrealba D., Morera D., Tort L., MacKenzie S., Roher N.
Comp. Biochem. Physiol. 182B:55-63(2015).
A characterization of the ZFL cell line and primary hepatocytes as in vitro liver cell models for the zebrafish (Danio rerio).
Eide M., Rusten M., Male R., Jensen K.H.M., Goksoyr A.
Aquat. Toxicol. 147:7-17(2014).
Derivation and characterization of a zebrafish liver cell line.";
Ghosh C., Zhou Y.L., Collodi P.
Cell Biol. Toxicol. 10:167-176(1994).
Cell cultures from zebrafish embryos and adult tissues.";
Bradford C.S., Sun L., Collodi P., Barnes D.W.
J. Tissue Cult. Methods 16:99-107(1994).