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FarageHomo sapiens (Human)Cancer cell line

Also known as: Farage Original Line, Farage OL, FARAGE

🤖 AI SummaryBased on 12 publications

Quick Overview

Human B-cell lymphoma cell line with trisomy 11 and unique immunophenotype.

Detailed Summary

The Farage cell line is a human B-cell lymphoma cell line established from a patient with diffuse large B-cell lymphoma. It exhibits trisomy 11 and lacks surface immunoglobulin expression while showing intracellular IgM and kappa chain expression. The cell line is characterized by the expression of B-cell surface markers such as CD19, CD20, CD22, and HLA-DR, but lacks T-cell and myeloid markers. Farage cells show distinct patterns of CD45 isoform expression and are used in studies related to B-cell differentiation and immunotherapy. The cell line has been utilized in research on microRNA profiles, genetic alterations, and immune checkpoint molecule expression, including PD-L1 and PD-L2. It is also involved in studies of cell cycle regulation, apoptosis, and tumor microenvironment interactions.

Research Applications

B-cell differentiation studiesImmunotherapy researchMicroRNA profilingGenetic alteration analysisImmune checkpoint molecule expressionCell cycle regulationApoptosis studiesTumor microenvironment interactions

Key Characteristics

Trisomy 11Lack of surface immunoglobulinIntracellular IgM and kappa chain expressionExpression of CD19, CD20, CD22, HLA-DRDistinct CD45 isoform patternsPD-L1 and PD-L2 expression

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3302
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	70
Age Category	Adult
Sex	Female

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Germinal Center B-Cell Type
OncoTree Code	GCB

DepMap Information

Source Type	ATCC
Source ID	ACH-001498_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

11,13

D16S539

11,12

D18S51

12,13

D19S433

14

D21S11

29

D2S1338

24,25

D3S1358

14,18

D5S818

12

D7S820

12

D8S1179

12

FGA

20,23

Penta D

9,12

Penta E

7,18

TH01

8,9

TPOX

9

vWA

14,15

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Genetic heterogeneity of diffuse large B-cell lymphoma.";

Dunson D.B., Dave S.S.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Kutok J.L., Shipp M.A.

Blood 116:3268-3277(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.

Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.

Int. J. Cancer 125:212-221(2009).

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

Regulation of the expression of CD45 isoforms in the Farage human B cell lymphoma line and its 10.6.1 subline.

Schlesinger M.

Leuk. Lymphoma 41:643-654(2001).

Molecular characterization of an unusual non-Hodgkin's B-lymphoma cell line ('Farage') lacking the ability to produce immunoglobulin polypeptide chains.

Laskov R.

Leuk. Lymphoma 21:485-495(1996).

Farage, a novel early B cell lymphoma cell line with trisomy 11.";

Okon E., Livni N., Schlesinger M.

Leuk. Lymphoma 6:513-521(1992).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

Web Resources