HMCBHomo sapiens (Human)Cancer cell line
Also known as: BOWES, Bowes melanoma cells, Human Melanoma Cell Bowes
🤖 AI SummaryBased on 6 publications
Quick Overview
Human cancer cell line with potential for drug sensitivity studies
Detailed Summary
The HMCB cell line is a human-derived cancer cell line that has been utilized in various research applications, particularly in the study of drug sensitivity and anticancer mechanisms. It is part of the Cancer Cell Line Encyclopedia (CCLE), which provides extensive genomic and pharmacological data for over 947 cancer cell lines. This cell line is notable for its role in identifying genetic predictors of drug response, including the correlation between BRAF mutations and sensitivity to MEK inhibitors. Additionally, HMCB has been involved in studies examining the relationship between genetic alterations and therapeutic outcomes, contributing to the development of personalized cancer treatment strategies. The cell line's genomic profile and drug response data make it a valuable resource for researchers investigating cancer biology and therapeutic interventions.
Research Applications
Drug sensitivity studiesGenomic profilingAnticancer mechanism investigationPersonalized treatment strategies
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used in identifying genetic predictors of drug responseCorrelation with BRAF mutations and MEK inhibitor sensitivity
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3317 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000931_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.His193Arg (c.578A>G) | Unspecified | Somatic mutation acquired during proliferation | PubMed=28445466 |
| MutationSimple | NRAS | p.Gln61Lys (c.181C>A) | Unspecified | Acquired during resistance selection process | PubMed=26214590 |
| MutationSimple | CDKN2A | p.Trp110Ter (c.330G>A) (p.Gly125Arg, c.373G>A) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8,11
D16S539
13
D18S51
11,12
D19S433
15
D21S11
29,30
D2S1338
18
D3S1358
15,17
D5S818
11,12
D7S820
11,13
D8S1179
10,13
FGA
23,25
Penta D
12,14
Penta E
10,13
TH01
9,9.3
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Web Resources
Anecdotal Information
- The Bowes cell line is famous for its use in the identification and purification of tissue-type plasminogen activator, tPA