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PfeifferHomo sapiens (Human)Cancer cell line

Also known as: PFEIFFER, Pfeifer (Occasionally.), Pfieffer

🤖 AI SummaryBased on 13 publications

Quick Overview

Human B-cell lymphoma cell line for cancer research

Detailed Summary

The Pfeiffer cell line is a human B-cell lymphoma cell line derived from a patient with diffuse large B-cell lymphoma (DLBCL). It is widely used in research to study the molecular mechanisms of B-cell malignancies, including the role of BCL-2 in apoptosis and resistance to therapies. The cell line has been utilized in studies examining the efficacy of BCL-2 inhibitors like venetoclax and the genetic heterogeneity of DLBCL. Additionally, it has been involved in investigations of somatic mutations and their impact on tumor biology, as well as in the characterization of protein expression profiles and their correlation with drug sensitivity. The Pfeiffer cell line is also part of large-scale genomic and proteomic studies, contributing to the understanding of cancer genomics and the development of targeted therapies.

Research Applications

Study of B-cell malignanciesInvestigation of BCL-2 function and resistance mechanismsEvaluation of BCL-2 inhibitors like venetoclaxAnalysis of genetic heterogeneity in DLBCLCharacterization of somatic mutations and their impact on tumor biologyProteomic and genomic profiling for drug sensitivity prediction

Key Characteristics

Expresses BCL-2Used in studies of apoptosis and drug resistancePart of large-scale genomic and proteomic studiesRelevant for understanding B-cell lymphoma genetics

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3326
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Diffuse Large B-Cell Lymphoma, NOS
OncoTree Code	DLBCLNOS

DepMap Information

Source Type	ATCC
Source ID	ACH-000140_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	APC	p.Arg1171Cys (c.3511C>T)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

11,12

D16S539

12

D18S51

13,14

D19S433

14

D21S11

28,32.2

D2S1338

19

D3S1358

13,18

D5S818

10,13

D7S820

8,12

D8S1179

12,14

FGA

22,23

Penta D

12,13

Penta E

14,17

TH01

9,9.3

TPOX

9

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Antitumor effects and mechanisms of 1,25(OH)2D3 in the Pfeiffer diffuse large B lymphoma cell line.

Han J., Tang Y.-H., Zhong M.-Z., Wu W.-L.

Mol. Med. Rep. 20:5064-5074(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.

Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.

Clin. Cancer Res. 24:3967-3980(2018).

Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.

Pham L.V.

Oncotarget 9:346-360(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

Genetic heterogeneity of diffuse large B-cell lymphoma.";

Dunson D.B., Dave S.S.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-kappaB-inducing kinase while activating both canonical and alternative nuclear factor-kappaB pathways.

Vega-Vazquez F., Medeiros L.J., Ford R.J. Jr.

Blood 117:200-210(2011).

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Kutok J.L., Shipp M.A.

Blood 116:3268-3277(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.

Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.

Int. J. Cancer 125:212-221(2009).

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines.

Gabay C., Ben-Bassat H., Schlesinger M., Laskov R.

Eur. J. Haematol. 63:180-191(1999).

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