TE-14Homo sapiens (Human)Cancer cell line

Also known as: TE14

🤖 AI SummaryBased on 6 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line

Detailed Summary

TE-14 is a human esophageal squamous cell carcinoma cell line established from a primary tumor. It is part of the TE-series cell lines, which are widely used in cancer research. The cell line exhibits characteristics of squamous cell carcinoma, including specific genetic alterations and molecular features. Research on TE-14 has contributed to understanding the mechanisms of esophageal carcinogenesis, particularly regarding the role of LRP1B in tumor suppression and the impact of genetic and epigenetic changes on cancer progression. The cell line is utilized in studies involving drug sensitivity, gene expression, and molecular profiling to identify potential therapeutic targets.

Research Applications

Cancer researchMolecular profilingDrug sensitivity studiesGene expression analysisTumor suppressor gene studies

Key Characteristics

Squamous cell carcinoma originLRP1B inactivationGenetic and epigenetic alterationsDrug response profiling

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3336
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	57
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000726_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown
MutationSimple	TP53	p.His179Arg (c.536A>G)	Unspecified	-	PubMed=35297208

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D5S818

D7S820

9,11

TH01

TPOX

9,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

DOI PubMed

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

DOI PubMed