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TE-4Homo sapiens (Human)Cancer cell line

Also known as: TE4

🤖 AI SummaryBased on 9 publications

Quick Overview

Human esophageal squamous cell carcinoma cell line with known genetic alterations.

Detailed Summary

The TE-4 cell line is a human esophageal squamous cell carcinoma cell line established from a primary tumor. It is part of the TE-series cell lines, which have been widely used in research on esophageal cancer. Studies have shown that TE-4 exhibits specific genetic alterations, including homozygous deletions and mutations in genes such as LRP1B and FAT, which are associated with tumor suppressor functions. These alterations contribute to the malignant phenotype and are critical for understanding the molecular mechanisms of esophageal carcinogenesis. The cell line is also noted for its distinct epigenetic modifications, such as hypermethylation of CpG islands, which can lead to gene silencing. TE-4 is utilized in studies investigating the role of these genetic and epigenetic changes in cancer progression and therapeutic responses.

Research Applications

Genetic and epigenetic studies of esophageal cancerInvestigation of tumor suppressor gene alterationsAnalysis of gene silencing mechanismsStudy of cancer progression and therapeutic responses

Key Characteristics

Homozygous deletions in tumor suppressor genesHypermethylation of CpG islandsExpression of specific oncogenes and tumor suppressor mutations

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3337
Species	Homo sapiens (Human)
Tissue Source	Esophagus[UBERON:UBERON_0001043]

Donor Information

Age	48
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000917_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly245Cys (c.733G>T)	Heterozygous	Somatic mutation acquired during proliferation	PubMed=18487078, PubMed=16020667, PubMed=15287027, PubMed=12884349, PubMed=1394225
MutationSimple	PTEN	p.Ter404Leuext*8 (c.1211G>T)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11

D13S317

11

D16S539

9,10

D5S818

10

D7S820

11

TH01

6

TPOX

8,11

vWA

14

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Lowe A.W., Beverloo H.B., van Dekken H., Tilanus H.W., Dinjens W.N.M.

Cancer Res. 67:7996-8001(2007).

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.

Hamakawa H.

Oncogene 26:5300-5308(2007).

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.

Cancer Res. 64:3741-3747(2004).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Molecular and cellular features of esophageal cancer cells.";

Nishihira T., Hashimoto Y., Katayama M., Mori S., Kuroki T.

J. Cancer Res. Clin. Oncol. 119:441-449(1993).

Human esophageal carcinoma cells have fewer, but higher affinity epidermal growth factor receptors.

Banks-Schlegel S.P., Quintero J.

J. Biol. Chem. 261:4359-4362(1986).