Lu-143Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 1 publications
Quick Overview
Human small cell lung cancer cell line with 5p13 amplification.
Detailed Summary
Lu-143 is a human small cell lung cancer (SCLC) cell line that exhibits amplification within the 5p13 region. This cell line was identified in a study analyzing DNA copy-number aberrations in 22 SCLC cell lines using comparative genomic hybridization (CGH). The 5p13 amplicon contains genes such as SKP2, which is frequently amplified and overexpressed in SCLC. SKP2 plays a critical role in cell cycle progression by targeting regulators like p27KIP1 for ubiquitin-mediated degradation. The amplification and overexpression of SKP2 in Lu-143 suggest its potential involvement in SCLC tumorigenesis. Research on this cell line has contributed to understanding the genetic mechanisms underlying SCLC progression and may provide insights for therapeutic strategies targeting SKP2.
Research Applications
Amplification analysisGene expression studiesCell cycle regulationOncogene research
Key Characteristics
5p13 amplificationSKP2 overexpressionSmall cell lung cancer model
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3348 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002074_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | c.782+1G>T | Homozygous | Splice donor mutation | Unknown, Unknown, PubMed=1565469, PubMed=1311061 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
8
D16S539
9
D5S818
11
D7S820
10,11
TH01
6
TPOX
11
vWA
17,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Hum. Cell 37:944-950(2024).
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Inazawa J.
Am. J. Pathol. 161:207-216(2002).
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Sugimura T., Terada M., Yokota J.
Oncogene 7:451-457(1992).