Lu-138Homo sapiens (Human)Cancer cell line
Also known as: LU-138, NCC-c-Lu-138
🤖 AI SummaryBased on 3 publications
Quick Overview
Human small cell lung cancer cell line with SKP2 amplification and overexpression.
Detailed Summary
Lu-138 is a human small cell lung cancer (SCLC) cell line derived from a patient with small cell lung cancer. It exhibits amplification and overexpression of the SKP2 gene, which plays a role in cell cycle regulation and tumorigenesis. The cell line shows high-level amplification at the 5p13 region, which includes the SKP2 gene. Research on Lu-138 has contributed to understanding the genetic alterations in SCLC, particularly the role of SKP2 in cancer progression. The cell line is used in studies investigating the molecular mechanisms of SCLC and potential therapeutic targets.
Research Applications
Genomic amplification studiesSKP2 gene function analysisCell cycle regulation in cancerTherapeutic target identification
Key Characteristics
Amplification of 5p13 regionOverexpression of SKP2Small cell lung cancer origin
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3350 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 78 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002075_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Leu (c.743G>T) | Unspecified | - | PubMed=18487078 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
8,11
D16S539
11
D5S818
10,12
D7S820
10,11
TH01
7,9
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Hum. Cell 37:944-950(2024).
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Inazawa J.
Am. J. Pathol. 161:207-216(2002).
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.
Int. J. Oncol. 15:927-934(1999).
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.
Jpn. J. Clin. Oncol. 16:203-212(1986).
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Sugimura T., Terada M., Yokota J.
Oncogene 7:451-457(1992).