KE-39Homo sapiens (Human)Cancer cell line
Also known as: KE39
🤖 AI SummaryBased on 4 publications
Quick Overview
Human gastric cancer cell line for research on ZAK isoform and 5-FU sensitivity.
Detailed Summary
KE-39 is a human gastric cancer cell line derived from a primary tumor, widely used in cancer research. It is notable for its role in studies involving the ZAK kinase isoform, particularly the TV1 variant, which shows preferential upregulation in gastric tumors and cell lines. Research on KE-39 has contributed to understanding the oncogenic properties of ZAK TV1 and its implications in cancer progression. Additionally, KE-39 has been utilized in studies examining 5-FU-based chemotherapy responses, highlighting its relevance in evaluating chemosensitivity and resistance mechanisms. These studies provide insights into potential therapeutic strategies for gastric cancer patients.
Research Applications
ZAK isoform analysis5-FU chemosensitivity studiesGastric cancer progressionOncogenic pathway investigation
Key Characteristics
ZAK TV1 isoform upregulation5-FU sensitivity profileGastric cancer origin
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3385 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 77 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Gastric adenocarcinoma |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Stomach Adenocarcinoma |
| OncoTree Code | STAD |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000507_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Val272Leu (c.814G>T) | Unspecified | - | PubMed=7732013 |
| MutationSimple | CTNNB1 | p.Asp32Asn (c.94G>A) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13
D13S317
8,10
D16S539
11
D18S51
14,15
D19S433
14.2,16.2
D21S11
30
D2S1338
22
D3S1358
17
D5S818
10
D7S820
11
D8S1179
11,16
FGA
22,23
Penta D
11
Penta E
18,23
TH01
7
TPOX
9,11
vWA
14
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Firestein R., Zhang Z.-M.
Nat. Commun. 5:3830.1-3830.8(2014).
A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.
Sato K., Iwaya T., Koeda K., Wakabayashi G.
PLoS ONE 9:E90155-E90155(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Establishment and characterization of strain KE-39 derived from human gastric cancer.
Okayasu I., Yasuda S.
Hum. Cell 7:227-232(1994).