SUM44PEHomo sapiens (Human)Cancer cell line
Also known as: 44PE, Sum44, SUM44, SUM 44, SUM-44, SUM-44 PE, SUM 44PE, SUM-44PE, Sum44PE
Quick Overview
SUM44PE is a human breast cancer cell line derived from invasive lobular carcinoma, characterized by E-cadherin loss and unique...
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_3424 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
| Subtype Features | luminal ER+ |
Disease Information
| Disease | Invasive breast lobular carcinoma |
|---|---|
| Lineage | Breast |
| Subtype | Breast Invasive Lobular Carcinoma |
| OncoTree Code | ILC |
DepMap Information
| Source Type | Asterand |
|---|---|
| Source ID | ACH-001395_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Glu28fs*16 (c.82_84del3insCA) | Unspecified | - | PubMed=16541312 |
| MutationSimple | CDH1 | p.Phe423Leufs*8 (c.1269delT) | Homozygous | - | PubMed=19593635 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base.
Duchinski K., Couch D., Gray J.W., Kappler C.S.
NPJ Breast Cancer 6:30.1-30.14(2020).
Comprehensive phenotypic characterization of human invasive lobular carcinoma cell lines in 2D and 3D cultures.
Jacobsen B.M., Tseng G.C.-C., Davidson N.E., Oesterreich S.
Cancer Res. 78:6209-6222(2018).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
Lobular breast cancer: molecular basis, mouse and cellular models.";
Christgen M., Derksen P.W.B.
Breast Cancer Res. 17:16.1-16.9(2015).
Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response.
Chandran U.R., Davidson N.E., Dabbs D.J., Welm A.L., Oesterreich S.
Cancer Res. 74:1463-1474(2014).
Modeling precision treatment of breast cancer.";
Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Genome Biol. 14:R110.1-R110.14(2013).
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Martens J.W.M.
Breast Cancer Res. 15:R33.1-R33.17(2013).
Phenotypic and molecular characterization of MCF10DCIS and SUM breast cancer cell lines.
Barnabas N., Cohen D.
Int. J. Breast Cancer 2013:872743.1-872743.16(2013).
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.
Breast Cancer Res. Treat. 121:53-64(2010).
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
Pollack J.R.
PLoS ONE 4:E6146-E6146(2009).
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.
Cancer Cell 10:515-527(2006).
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.
Breast Cancer Res. Treat. 99:97-101(2006).
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
van den Ouweland A.M.W., Merajver S.D., Ethier S.P., Schutte M.
Cancer Res. 66:41-45(2006).
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Edwards P.A.W., Caldas C.
Carcinogenesis 26:923-930(2005).
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Edwards P.A.W., Chaffanet M.
Genes Chromosomes Cancer 37:333-345(2003).
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.
Birnbaum D., Chaffanet M.
Genes Chromosomes Cancer 35:204-218(2002).
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Gooden G.C., Ethier S.P., Kallioniemi A.H., Kallioniemi O.-P.
Cancer Res. 60:4519-4525(2000).
Molecular cytogenetic analysis of 11 new breast cancer cell lines.";
Kallioniemi O.-P., Ethier S.P.
Br. J. Cancer 81:1328-1334(1999).
Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.
Ignatoski K.M.W., Ethier S.P.
Breast Cancer Res. Treat. 54:173-182(1999).
Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media.
Ethier S.P., Mahacek M.L., Gullick W.J., Frank T.S., Weber B.L.
Cancer Res. 53:627-635(1993).