Back to Cell Types

HPACHomo sapiens (Human)Cancer cell line

Also known as: Hpac

🤖 AI SummaryBased on 9 publications

Quick Overview

HPAC is a human pancreatic ductal adenocarcinoma cell line derived from a xenograft, used for cancer research.

Detailed Summary

HPAC is a human pancreatic ductal adenocarcinoma cell line established from a xenograft of a primary pancreatic tumor. It exhibits characteristics of pancreatic ductal epithelial cells, including the expression of specific antigens like CA 19-9 and DU-PAN-2. HPAC cells form monolayers with polarized epithelial morphology and are sensitive to glucocorticoids, which inhibit their DNA synthesis and proliferation. The cell line is used in studies related to pancreatic cancer biology, drug testing, and understanding the role of glucocorticoids in tumor regulation. HPAC has been utilized in research to investigate metabolic profiles, genetic alterations, and therapeutic responses in pancreatic cancer.

Research Applications

Cancer researchDrug testingGlucocorticoid response studiesMetabolic profilingGenetic alteration analysis

Key Characteristics

Glucocorticoid sensitivityExpression of pancreatic ductal markersPolarized epithelial morphologyIn vitro growth characteristics

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3517
Species	Homo sapiens (Human)
Tissue Source	Pancreas[UBERON:UBERON_0001264]

Donor Information

Age	64
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Pancreatic adenocarcinoma
Lineage	Pancreas
Subtype	Pancreatic Adenocarcinoma
OncoTree Code	PAAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000270_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757
MutationSimple	CDKN2A	p.Glu120Ter (c.358G>T)	Unspecified	-	from parent cell line KYSE-30

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

13

D13S317

11

D16S539

9,10

D18S51

16

D19S433

14

D21S11

30

D2S1338

19,23

D3S1358

15,17

D5S818

12

D7S820

10,12

D8S1179

12,14

FGA

24

Penta D

13

Penta E

15,17

TH01

9.3

TPOX

10,11

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling.

Biankin A.V., Wu J.-M., Daly R.J.

Mol. Cell. Proteomics 15:2671-2685(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

HPAC, a new human glucocorticoid-sensitive pancreatic ductal adenocarcinoma cell line.

Gower W.R. Jr., Risch R.M., Godellas C.V., Fabri P.J.

In Vitro Cell. Dev. Biol. Anim. 30:151-161(1994).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.

Linnartz R., Zubel A., Slamon D.J., Finn R.S.

Br. J. Cancer 111:1788-1801(2014).

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Rottapel R., Neel B.G., Moffat J.

Cancer Discov. 2:172-189(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Phenotype and genotype of pancreatic cancer cell lines.";

Scaife C.L., Firpo M.A., Mulvihill S.J.

Pancreas 39:425-435(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.

Hirohashi S.

Pancreas 29:193-203(2004).

The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.

Yamada M., Fujii K., Koyama K., Hirohashi S., Kondo T.

J. Proteomics Bioinformatics 2:1-18(2009).

Web Resources

dpsc.ccbr.utoronto.ca